A novel probe to assess cytosolic entry of exogenous proteins

The mechanism of protein dislocation into the cytosol during antigen cross-presentation is poorly understood. Here the authors engineer a dislocation reporter fusing a glycosylated luciferase variant to the Fc region of IgG1, and find that dislocation is the rate limiting step in cross-presentation.

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Detalles Bibliográficos
Autores principales:	Qiao Lu, Jeff E. Grotzke, Peter Cresswell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c22ebab140ef4bcd9fed474379da587d
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id	oai:doaj.org-article:c22ebab140ef4bcd9fed474379da587d
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spelling	oai:doaj.org-article:c22ebab140ef4bcd9fed474379da587d2021-12-02T14:39:45ZA novel probe to assess cytosolic entry of exogenous proteins10.1038/s41467-018-05556-z2041-1723https://doaj.org/article/c22ebab140ef4bcd9fed474379da587d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05556-zhttps://doaj.org/toc/2041-1723The mechanism of protein dislocation into the cytosol during antigen cross-presentation is poorly understood. Here the authors engineer a dislocation reporter fusing a glycosylated luciferase variant to the Fc region of IgG1, and find that dislocation is the rate limiting step in cross-presentation.Qiao LuJeff E. GrotzkePeter CresswellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiao Lu Jeff E. Grotzke Peter Cresswell A novel probe to assess cytosolic entry of exogenous proteins
description	The mechanism of protein dislocation into the cytosol during antigen cross-presentation is poorly understood. Here the authors engineer a dislocation reporter fusing a glycosylated luciferase variant to the Fc region of IgG1, and find that dislocation is the rate limiting step in cross-presentation.
format	article
author	Qiao Lu Jeff E. Grotzke Peter Cresswell
author_facet	Qiao Lu Jeff E. Grotzke Peter Cresswell
author_sort	Qiao Lu
title	A novel probe to assess cytosolic entry of exogenous proteins
title_short	A novel probe to assess cytosolic entry of exogenous proteins
title_full	A novel probe to assess cytosolic entry of exogenous proteins
title_fullStr	A novel probe to assess cytosolic entry of exogenous proteins
title_full_unstemmed	A novel probe to assess cytosolic entry of exogenous proteins
title_sort	novel probe to assess cytosolic entry of exogenous proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c22ebab140ef4bcd9fed474379da587d
work_keys_str_mv	AT qiaolu anovelprobetoassesscytosolicentryofexogenousproteins AT jeffegrotzke anovelprobetoassesscytosolicentryofexogenousproteins AT petercresswell anovelprobetoassesscytosolicentryofexogenousproteins AT qiaolu novelprobetoassesscytosolicentryofexogenousproteins AT jeffegrotzke novelprobetoassesscytosolicentryofexogenousproteins AT petercresswell novelprobetoassesscytosolicentryofexogenousproteins
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A novel probe to assess cytosolic entry of exogenous proteins

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