Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
Abstract Pharmacological levels of ascorbate have long been suggested as a potential treatment of cancer. However, we observed that EC50 of ascorbate was at a similar level for cultured healthy melanocytes and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer. Loss o...
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Main Authors: | Sushmita Mustafi, David W. Sant, Zhao-Jun Liu, Gaofeng Wang |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
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Online Access: | https://doaj.org/article/c22ec85d07c34fba99d8b4a8dc80b97d |
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