Functionalized carbon nanotubes: biomedical applications
Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanot...
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Dove Medical Press
2012
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oai:doaj.org-article:c23207bebc3b4e19a523fa7bc364767d2021-12-02T08:07:35ZFunctionalized carbon nanotubes: biomedical applications1176-91141178-2013https://doaj.org/article/c23207bebc3b4e19a523fa7bc364767d2012-10-01T00:00:00Zhttp://www.dovepress.com/functionalized-carbon-nanotubes-biomedical-applications-a11217https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applicationsVardharajula SAli SZTiwari PMEroğlu EVig KDennis VASingh SRDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5361-5374 (2012) |
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Medicine (General) R5-920 Vardharajula S Ali SZ Tiwari PM Eroğlu E Vig K Dennis VA Singh SR Functionalized carbon nanotubes: biomedical applications |
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Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applications |
format |
article |
author |
Vardharajula S Ali SZ Tiwari PM Eroğlu E Vig K Dennis VA Singh SR |
author_facet |
Vardharajula S Ali SZ Tiwari PM Eroğlu E Vig K Dennis VA Singh SR |
author_sort |
Vardharajula S |
title |
Functionalized carbon nanotubes: biomedical applications |
title_short |
Functionalized carbon nanotubes: biomedical applications |
title_full |
Functionalized carbon nanotubes: biomedical applications |
title_fullStr |
Functionalized carbon nanotubes: biomedical applications |
title_full_unstemmed |
Functionalized carbon nanotubes: biomedical applications |
title_sort |
functionalized carbon nanotubes: biomedical applications |
publisher |
Dove Medical Press |
publishDate |
2012 |
url |
https://doaj.org/article/c23207bebc3b4e19a523fa7bc364767d |
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