Functionalized carbon nanotubes: biomedical applications

Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanot...

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Autores principales: Vardharajula S, Ali SZ, Tiwari PM, Eroğlu E, Vig K, Dennis VA, Singh SR
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Lenguaje:EN
Publicado: Dove Medical Press 2012
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Acceso en línea:https://doaj.org/article/c23207bebc3b4e19a523fa7bc364767d
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spelling oai:doaj.org-article:c23207bebc3b4e19a523fa7bc364767d2021-12-02T08:07:35ZFunctionalized carbon nanotubes: biomedical applications1176-91141178-2013https://doaj.org/article/c23207bebc3b4e19a523fa7bc364767d2012-10-01T00:00:00Zhttp://www.dovepress.com/functionalized-carbon-nanotubes-biomedical-applications-a11217https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applicationsVardharajula SAli SZTiwari PMEroğlu EVig KDennis VASingh SRDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5361-5374 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Vardharajula S
Ali SZ
Tiwari PM
Eroğlu E
Vig K
Dennis VA
Singh SR
Functionalized carbon nanotubes: biomedical applications
description Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applications
format article
author Vardharajula S
Ali SZ
Tiwari PM
Eroğlu E
Vig K
Dennis VA
Singh SR
author_facet Vardharajula S
Ali SZ
Tiwari PM
Eroğlu E
Vig K
Dennis VA
Singh SR
author_sort Vardharajula S
title Functionalized carbon nanotubes: biomedical applications
title_short Functionalized carbon nanotubes: biomedical applications
title_full Functionalized carbon nanotubes: biomedical applications
title_fullStr Functionalized carbon nanotubes: biomedical applications
title_full_unstemmed Functionalized carbon nanotubes: biomedical applications
title_sort functionalized carbon nanotubes: biomedical applications
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/c23207bebc3b4e19a523fa7bc364767d
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AT tiwaripm functionalizedcarbonnanotubesbiomedicalapplications
AT eroglue functionalizedcarbonnanotubesbiomedicalapplications
AT vigk functionalizedcarbonnanotubesbiomedicalapplications
AT dennisva functionalizedcarbonnanotubesbiomedicalapplications
AT singhsr functionalizedcarbonnanotubesbiomedicalapplications
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