Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy

Michael Javaheri1, Rahul N Khurana1, Rizwan A Bhatti1, Jennifer I Lim21Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; 2Eye and Ear Infirmary, Department of Ophthalmology, University of Illi...

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Autores principales:	Michael Javaheri, Rahul N Khurana, Rizwan A Bhatti, Jennifer I Lim
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c23283317de4461aa860da7289b8eab7
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spelling	oai:doaj.org-article:c23283317de4461aa860da7289b8eab72021-12-02T00:44:59ZOptical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy1177-54671177-5483https://doaj.org/article/c23283317de4461aa860da7289b8eab72008-06-01T00:00:00Zhttp://www.dovepress.com/optical-coherence-tomography-findings-in-paraneoplastic-pseudovitellif-a1802https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Michael Javaheri1, Rahul N Khurana1, Rizwan A Bhatti1, Jennifer I Lim21Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; 2Eye and Ear Infirmary, Department of Ophthalmology, University of Illinois, Chicago, IL, USAPurpose: To report an unusual case of paraneoplastic pseudovitelliform lesions associated with melanoma-associated retinopathy (MAR).Design: Observational case report.Methods: Retrospective review of the ophthalmic examination, fundus photography, fluorescein angiography, electroretinogram (ERG), and optical coherence tomography (OCT) of a patient with MAR.Results: A 65-year-old Caucasian man with a two-year history of metastatic melanoma was referred for evaluation of a six-month history of nyctalopia. Funduscopic examination in both eyes revealed multiple, creamy, yellow, pseudovitelliform lesions in the posterior pole, varying in size from 100&ndash;500 &micro;m, at the level of the outer retinal/retinal pigment epithelium (RPE) junction, coalescing along the inferior portion, with overlying macular neurosensory detachments. OCT showed bilateral macular neurosensory detachments with multiple small areas of high refl ectivity at the level of the outer retinal/RPE junction. ERG demonstrated a selective loss of the b-wave and a normal a-wave under dark adapted, scotopic conditions.Conclusion: Clinicians should be aware of this atypical presentation of MAR that may include pseudovitelliform retinal findings.Keywords: cancer-associated retinopathy, melanoma-associated retinopathy, optical coherence tomography, paraneoplastic syndrome, paraneoplastic pseudovitelliform retinopathy Michael JavaheriRahul N KhuranaRizwan A BhattiJennifer I LimDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 2, Pp 461-463 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Michael Javaheri Rahul N Khurana Rizwan A Bhatti Jennifer I Lim Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
description	Michael Javaheri1, Rahul N Khurana1, Rizwan A Bhatti1, Jennifer I Lim21Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; 2Eye and Ear Infirmary, Department of Ophthalmology, University of Illinois, Chicago, IL, USAPurpose: To report an unusual case of paraneoplastic pseudovitelliform lesions associated with melanoma-associated retinopathy (MAR).Design: Observational case report.Methods: Retrospective review of the ophthalmic examination, fundus photography, fluorescein angiography, electroretinogram (ERG), and optical coherence tomography (OCT) of a patient with MAR.Results: A 65-year-old Caucasian man with a two-year history of metastatic melanoma was referred for evaluation of a six-month history of nyctalopia. Funduscopic examination in both eyes revealed multiple, creamy, yellow, pseudovitelliform lesions in the posterior pole, varying in size from 100&ndash;500 &micro;m, at the level of the outer retinal/retinal pigment epithelium (RPE) junction, coalescing along the inferior portion, with overlying macular neurosensory detachments. OCT showed bilateral macular neurosensory detachments with multiple small areas of high refl ectivity at the level of the outer retinal/RPE junction. ERG demonstrated a selective loss of the b-wave and a normal a-wave under dark adapted, scotopic conditions.Conclusion: Clinicians should be aware of this atypical presentation of MAR that may include pseudovitelliform retinal findings.Keywords: cancer-associated retinopathy, melanoma-associated retinopathy, optical coherence tomography, paraneoplastic syndrome, paraneoplastic pseudovitelliform retinopathy
format	article
author	Michael Javaheri Rahul N Khurana Rizwan A Bhatti Jennifer I Lim
author_facet	Michael Javaheri Rahul N Khurana Rizwan A Bhatti Jennifer I Lim
author_sort	Michael Javaheri
title	Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
title_short	Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
title_full	Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
title_fullStr	Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
title_full_unstemmed	Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
title_sort	optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/c23283317de4461aa860da7289b8eab7
work_keys_str_mv	AT michaeljavaheri opticalcoherencetomographyfindingsinparaneoplasticpseudovitelliformlesionsinmelanomaassociatedretinopathy AT rahulnkhurana opticalcoherencetomographyfindingsinparaneoplasticpseudovitelliformlesionsinmelanomaassociatedretinopathy AT rizwanabhatti opticalcoherencetomographyfindingsinparaneoplasticpseudovitelliformlesionsinmelanomaassociatedretinopathy AT jenniferilim opticalcoherencetomographyfindingsinparaneoplasticpseudovitelliformlesionsinmelanomaassociatedretinopathy
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Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy

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