Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease

23 women with a chronic form of coronary heart disease (CHD) were examined before and after two months of taking simvastatin at doses of 40 and 80 mg/day. Regardless of the dosage the reduction in total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) and atherogenic index (Al) wa...

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Autores principales:	A. M. Dygai, M. Yu. Kotlovskiy, D. A. Kirichenko, I. Yu. Yakimovitch, D. S. Tereshina, Yu. V. Kotlovskiy, V. N. Titov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	statins fatty acids lipid spectrum coronary heart disease Science Q
Acceso en línea:	https://doaj.org/article/c234296490a64ff2b511ed32bc105907
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spelling	oai:doaj.org-article:c234296490a64ff2b511ed32bc1059072021-11-23T06:14:29ZEffect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease2541-94202587-9596https://doaj.org/article/c234296490a64ff2b511ed32bc1059072013-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1633https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-959623 women with a chronic form of coronary heart disease (CHD) were examined before and after two months of taking simvastatin at doses of 40 and 80 mg/day. Regardless of the dosage the reduction in total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) and atherogenic index (Al) was found that pointed at the strengthening of receptor-mediated endocytosis in LDL-C cells with all portable fatty acids (FA) in them by apoB-100 cells, in various forms of esters. The spectrum of FA in the erythrocyte membrane phospholipids (FL) was researched by gas-liquid chromatography-mass spectrometry. Redistribution of FA was revealed after treatment with different doses: reduction of the unsaturation index (UI) of the membranes erythrocytes indicated a violation of physical, chemical and functional properties of cell membranes. The content of the FA-membrane substrates and substrates of vitamin F, triglycerol substrates (TGL) decreased and FA-energy substrates cells increased. Probably, the ability of statins to activate the desaturase enzymes had an effect of the increasing of long-chain ω-9 FA content. In this case the reduction of oleic ω-9 FA influenced the reduction of TGL. Unlike doses of 40 mg/day treatment at a dosage of 80 mg/day in women resulted the increase of relation ω-3/ω-6 LC and the decrease of dihomo-γ-linolenic LCD. It indicated the formation of favorable conditions of the normalization of cell function in vivo. Under these conditions the level of palmitic FA and, correspondingly, the activity of atheromatosis decreased.A. M. DygaiM. Yu. KotlovskiyD. A. KirichenkoI. Yu. YakimovitchD. S. TereshinaYu. V. KotlovskiyV. N. TitovScientific Сentre for Family Health and Human Reproduction Problemsarticlestatinsfatty acidslipid spectrumcoronary heart diseaseScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 22-28 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	statins fatty acids lipid spectrum coronary heart disease Science Q
spellingShingle	statins fatty acids lipid spectrum coronary heart disease Science Q A. M. Dygai M. Yu. Kotlovskiy D. A. Kirichenko I. Yu. Yakimovitch D. S. Tereshina Yu. V. Kotlovskiy V. N. Titov Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
description	23 women with a chronic form of coronary heart disease (CHD) were examined before and after two months of taking simvastatin at doses of 40 and 80 mg/day. Regardless of the dosage the reduction in total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) and atherogenic index (Al) was found that pointed at the strengthening of receptor-mediated endocytosis in LDL-C cells with all portable fatty acids (FA) in them by apoB-100 cells, in various forms of esters. The spectrum of FA in the erythrocyte membrane phospholipids (FL) was researched by gas-liquid chromatography-mass spectrometry. Redistribution of FA was revealed after treatment with different doses: reduction of the unsaturation index (UI) of the membranes erythrocytes indicated a violation of physical, chemical and functional properties of cell membranes. The content of the FA-membrane substrates and substrates of vitamin F, triglycerol substrates (TGL) decreased and FA-energy substrates cells increased. Probably, the ability of statins to activate the desaturase enzymes had an effect of the increasing of long-chain ω-9 FA content. In this case the reduction of oleic ω-9 FA influenced the reduction of TGL. Unlike doses of 40 mg/day treatment at a dosage of 80 mg/day in women resulted the increase of relation ω-3/ω-6 LC and the decrease of dihomo-γ-linolenic LCD. It indicated the formation of favorable conditions of the normalization of cell function in vivo. Under these conditions the level of palmitic FA and, correspondingly, the activity of atheromatosis decreased.
format	article
author	A. M. Dygai M. Yu. Kotlovskiy D. A. Kirichenko I. Yu. Yakimovitch D. S. Tereshina Yu. V. Kotlovskiy V. N. Titov
author_facet	A. M. Dygai M. Yu. Kotlovskiy D. A. Kirichenko I. Yu. Yakimovitch D. S. Tereshina Yu. V. Kotlovskiy V. N. Titov
author_sort	A. M. Dygai
title	Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
title_short	Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
title_full	Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
title_fullStr	Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
title_full_unstemmed	Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
title_sort	effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/c234296490a64ff2b511ed32bc105907
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Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease

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