Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography

Ran Liu,1 Cuiyun Jin,2 Fengjuan Song,2 Jing Liu1,31Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China; 2College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, China; 3Key Laboratory of Cryogenics, Technical Instit...

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Autores principales:	Liu J, Song F, Jin C, Liu R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c2398230c2754999afb87fa059c44ee3
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spelling	oai:doaj.org-article:c2398230c2754999afb87fa059c44ee32021-12-02T00:12:15ZNanoparticle-enhanced electrical impedance detection and its potential significance in image tomography1176-91141178-2013https://doaj.org/article/c2398230c2754999afb87fa059c44ee32013-01-01T00:00:00Zhttp://www.dovepress.com/nanoparticle-enhanced-electrical-impedance-detection-and-its-potential-a11853https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ran Liu,1 Cuiyun Jin,2 Fengjuan Song,2 Jing Liu1,31Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China; 2College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, China; 3Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, ChinaAbstract: The conductivity and permittivity of tumors are known to differ significantly from those of normal tissues. Electrical impedance tomography (EIT) is a relatively new imaging method for exploiting these differences. However, the accuracy of data capture is one of the difficult problems urgently to be solved in the clinical application of EIT technology. A new concept of EIT sensitizers is put forward in this paper with the goal of expanding the contrast ratio of tumor and healthy tissue to enhance EIT imaging quality. The use of nanoparticles for changing tumor characteristics and determining the infiltration vector for easier detection has been widely accepted in the biomedical field. Ultra-pure water, normal saline, and gold nanoparticles, three kinds of material with large differences in electrical characteristics, are considered as sensitizers and undergo mathematical model analysis and animal experimentation. Our preliminary results suggest that nanoparticles are promising for sensitization work. Furthermore, in experimental and simulation results, we found that we should select different sensitizers for the detection of different types and stages of tumor.Keywords: EIT, nanoparticle sensitizer, tumor detection, EMF analysisLiu JSong FJin CLiu RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 33-38 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liu J Song F Jin C Liu R Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
description	Ran Liu,1 Cuiyun Jin,2 Fengjuan Song,2 Jing Liu1,31Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China; 2College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, China; 3Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, ChinaAbstract: The conductivity and permittivity of tumors are known to differ significantly from those of normal tissues. Electrical impedance tomography (EIT) is a relatively new imaging method for exploiting these differences. However, the accuracy of data capture is one of the difficult problems urgently to be solved in the clinical application of EIT technology. A new concept of EIT sensitizers is put forward in this paper with the goal of expanding the contrast ratio of tumor and healthy tissue to enhance EIT imaging quality. The use of nanoparticles for changing tumor characteristics and determining the infiltration vector for easier detection has been widely accepted in the biomedical field. Ultra-pure water, normal saline, and gold nanoparticles, three kinds of material with large differences in electrical characteristics, are considered as sensitizers and undergo mathematical model analysis and animal experimentation. Our preliminary results suggest that nanoparticles are promising for sensitization work. Furthermore, in experimental and simulation results, we found that we should select different sensitizers for the detection of different types and stages of tumor.Keywords: EIT, nanoparticle sensitizer, tumor detection, EMF analysis
format	article
author	Liu J Song F Jin C Liu R
author_facet	Liu J Song F Jin C Liu R
author_sort	Liu J
title	Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
title_short	Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
title_full	Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
title_fullStr	Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
title_full_unstemmed	Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
title_sort	nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c2398230c2754999afb87fa059c44ee3
work_keys_str_mv	AT liuj nanoparticleenhancedelectricalimpedancedetectionanditspotentialsignificanceinimagetomography AT songf nanoparticleenhancedelectricalimpedancedetectionanditspotentialsignificanceinimagetomography AT jinc nanoparticleenhancedelectricalimpedancedetectionanditspotentialsignificanceinimagetomography AT liur nanoparticleenhancedelectricalimpedancedetectionanditspotentialsignificanceinimagetomography
_version_	1718403888276570112

Nanoparticle-enhanced electrical impedance detection and its potential significance in image tomography

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