Presence of complete murine viral genome sequences in patient-derived xenografts

Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples...

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Autores principales:	Zihao Yuan, Xuejun Fan, Jay-Jiguang Zhu, Tong-Ming Fu, Jiaqian Wu, Hua Xu, Ningyan Zhang, Zhiqiang An, W. Jim Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c239a456dafd4db3ab6b1fee821051bc
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spelling	oai:doaj.org-article:c239a456dafd4db3ab6b1fee821051bc2021-12-02T18:18:03ZPresence of complete murine viral genome sequences in patient-derived xenografts10.1038/s41467-021-22200-52041-1723https://doaj.org/article/c239a456dafd4db3ab6b1fee821051bc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22200-5https://doaj.org/toc/2041-1723Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples with high virus load.Zihao YuanXuejun FanJay-Jiguang ZhuTong-Ming FuJiaqian WuHua XuNingyan ZhangZhiqiang AnW. Jim ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng Presence of complete murine viral genome sequences in patient-derived xenografts
description	Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples with high virus load.
format	article
author	Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng
author_facet	Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng
author_sort	Zihao Yuan
title	Presence of complete murine viral genome sequences in patient-derived xenografts
title_short	Presence of complete murine viral genome sequences in patient-derived xenografts
title_full	Presence of complete murine viral genome sequences in patient-derived xenografts
title_fullStr	Presence of complete murine viral genome sequences in patient-derived xenografts
title_full_unstemmed	Presence of complete murine viral genome sequences in patient-derived xenografts
title_sort	presence of complete murine viral genome sequences in patient-derived xenografts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c239a456dafd4db3ab6b1fee821051bc
work_keys_str_mv	AT zihaoyuan presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT xuejunfan presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT jayjiguangzhu presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT tongmingfu presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT jiaqianwu presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT huaxu presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT ningyanzhang presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT zhiqiangan presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts AT wjimzheng presenceofcompletemurineviralgenomesequencesinpatientderivedxenografts
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Presence of complete murine viral genome sequences in patient-derived xenografts

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