Current Understanding of Nasal Epithelial Cell Mis-Differentiation

Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, GermanyCorrespondence: Agmal ScherzadDepartment of Otorhinolaryngology, Plastic, Aesthe...

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Autores principales:	Scherzad A, Hagen R, Hackenberg S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nasal mucosal barrier function tight junction epithelial-mesenchymal transition microbiome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c23c618429534d64a0f5e6f56bd3a852
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spelling	oai:doaj.org-article:c23c618429534d64a0f5e6f56bd3a8522021-12-02T08:18:14ZCurrent Understanding of Nasal Epithelial Cell Mis-Differentiation1178-7031https://doaj.org/article/c23c618429534d64a0f5e6f56bd3a8522019-12-01T00:00:00Zhttps://www.dovepress.com/current-understanding-of-nasal-epithelial-cell-mis-differentiation-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, GermanyCorrespondence: Agmal ScherzadDepartment of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, GermanyEmail Scherzad_A@ukw.deAbstract: The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial–mesenchymal transition and nasal microbiome.Keywords: nasal mucosal barrier function, tight junction, epithelial–mesenchymal transition, microbiomeScherzad AHagen RHackenberg SDove Medical Pressarticlenasal mucosal barrier functiontight junctionepithelial-mesenchymal transitionmicrobiomePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 12, Pp 309-317 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nasal mucosal barrier function tight junction epithelial-mesenchymal transition microbiome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	nasal mucosal barrier function tight junction epithelial-mesenchymal transition microbiome Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Scherzad A Hagen R Hackenberg S Current Understanding of Nasal Epithelial Cell Mis-Differentiation
description	Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, GermanyCorrespondence: Agmal ScherzadDepartment of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, GermanyEmail Scherzad_A@ukw.deAbstract: The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial–mesenchymal transition and nasal microbiome.Keywords: nasal mucosal barrier function, tight junction, epithelial–mesenchymal transition, microbiome
format	article
author	Scherzad A Hagen R Hackenberg S
author_facet	Scherzad A Hagen R Hackenberg S
author_sort	Scherzad A
title	Current Understanding of Nasal Epithelial Cell Mis-Differentiation
title_short	Current Understanding of Nasal Epithelial Cell Mis-Differentiation
title_full	Current Understanding of Nasal Epithelial Cell Mis-Differentiation
title_fullStr	Current Understanding of Nasal Epithelial Cell Mis-Differentiation
title_full_unstemmed	Current Understanding of Nasal Epithelial Cell Mis-Differentiation
title_sort	current understanding of nasal epithelial cell mis-differentiation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c23c618429534d64a0f5e6f56bd3a852
work_keys_str_mv	AT scherzada currentunderstandingofnasalepithelialcellmisdifferentiation AT hagenr currentunderstandingofnasalepithelialcellmisdifferentiation AT hackenbergs currentunderstandingofnasalepithelialcellmisdifferentiation
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Current Understanding of Nasal Epithelial Cell Mis-Differentiation

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