Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer

Abstract Although numerous studies have highlighted the prognostic values of various inflammation-related markers, clinical significance remains to be elucidated. The prognostic values of inflammation-related biomarkers for rectal cancer were investigated in this study. A total of 448 patients with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takehito Yamamoto, Kenji Kawada, Koya Hida, Ryo Matsusue, Yoshiro Itatani, Rei Mizuno, Takashi Yamaguchi, Iwao Ikai, Yoshiharu Sakai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c23d7235fea24a74aab094fdba9df8d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c23d7235fea24a74aab094fdba9df8d3
record_format	dspace
spelling	oai:doaj.org-article:c23d7235fea24a74aab094fdba9df8d32021-12-02T15:53:59ZCombination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer10.1038/s41598-021-84475-42045-2322https://doaj.org/article/c23d7235fea24a74aab094fdba9df8d32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84475-4https://doaj.org/toc/2045-2322Abstract Although numerous studies have highlighted the prognostic values of various inflammation-related markers, clinical significance remains to be elucidated. The prognostic values of inflammation-related biomarkers for rectal cancer were investigated in this study. A total of 448 patients with stage II/III rectal cancer undergoing curative resection were enrolled from the discovery cohort (n = 240) and validation cohort (n = 208). We comprehensively compared the prognostic values of 11 inflammation-related markers-derived from neutrophil, lymphocyte, platelet, monocyte, albumin, and C-reactive protein for overall survival (OS) and recurrence-free survival (RFS). Among 11 inflammation-related markers, only “lymphocyte × albumin (LA)” was significantly associated with both OS and RFS in the discovery cohort (P = 0.007 and 0.015, respectively). Multivariate analysis indicated that low LA was significantly associated with poor OS (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09–4.58, P = 0.025), and poor RFS (HR 1.61, 95% CI 1.01–2.80, P = 0.048). Furthermore, using the discovery cohort, we confirmed that low LA was significantly associated with poor OS (HR 2.89, 95% CI 1.42–6.00, P = 0.002), and poor RFS (HR 1.79, 95% CI 1.04–2.95, P = 0.034). LA can be a novel prognostic biomarker for stage II/III rectal cancer.Takehito YamamotoKenji KawadaKoya HidaRyo MatsusueYoshiro ItataniRei MizunoTakashi YamaguchiIwao IkaiYoshiharu SakaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takehito Yamamoto Kenji Kawada Koya Hida Ryo Matsusue Yoshiro Itatani Rei Mizuno Takashi Yamaguchi Iwao Ikai Yoshiharu Sakai Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
description	Abstract Although numerous studies have highlighted the prognostic values of various inflammation-related markers, clinical significance remains to be elucidated. The prognostic values of inflammation-related biomarkers for rectal cancer were investigated in this study. A total of 448 patients with stage II/III rectal cancer undergoing curative resection were enrolled from the discovery cohort (n = 240) and validation cohort (n = 208). We comprehensively compared the prognostic values of 11 inflammation-related markers-derived from neutrophil, lymphocyte, platelet, monocyte, albumin, and C-reactive protein for overall survival (OS) and recurrence-free survival (RFS). Among 11 inflammation-related markers, only “lymphocyte × albumin (LA)” was significantly associated with both OS and RFS in the discovery cohort (P = 0.007 and 0.015, respectively). Multivariate analysis indicated that low LA was significantly associated with poor OS (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09–4.58, P = 0.025), and poor RFS (HR 1.61, 95% CI 1.01–2.80, P = 0.048). Furthermore, using the discovery cohort, we confirmed that low LA was significantly associated with poor OS (HR 2.89, 95% CI 1.42–6.00, P = 0.002), and poor RFS (HR 1.79, 95% CI 1.04–2.95, P = 0.034). LA can be a novel prognostic biomarker for stage II/III rectal cancer.
format	article
author	Takehito Yamamoto Kenji Kawada Koya Hida Ryo Matsusue Yoshiro Itatani Rei Mizuno Takashi Yamaguchi Iwao Ikai Yoshiharu Sakai
author_facet	Takehito Yamamoto Kenji Kawada Koya Hida Ryo Matsusue Yoshiro Itatani Rei Mizuno Takashi Yamaguchi Iwao Ikai Yoshiharu Sakai
author_sort	Takehito Yamamoto
title	Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
title_short	Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
title_full	Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
title_fullStr	Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
title_full_unstemmed	Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
title_sort	combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c23d7235fea24a74aab094fdba9df8d3
work_keys_str_mv	AT takehitoyamamoto combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT kenjikawada combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT koyahida combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT ryomatsusue combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT yoshiroitatani combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT reimizuno combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT takashiyamaguchi combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT iwaoikai combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer AT yoshiharusakai combinationoflymphocytecountandalbuminconcentrationasanewprognosticbiomarkerforrectalcancer
_version_	1718385474217705472

Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer

Ejemplares similares