ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.

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Autores principales:	Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf0689
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spelling	oai:doaj.org-article:c23eacb750254746b5eeb2cdfdaf06892021-12-02T15:16:22ZZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK110.1038/s41467-020-20357-z2041-1723https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf06892021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20357-zhttps://doaj.org/toc/2041-1723Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.Hayley I. MuendleinWilson M. ConnollyZoie MagriIrina SmirnovaVladimir IlyukhaAvishekh GautamAlexei DegterevAlexander PoltorakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
description	Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
format	article
author	Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak
author_facet	Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak
author_sort	Hayley I. Muendlein
title	ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
title_short	ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
title_full	ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
title_fullStr	ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
title_full_unstemmed	ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
title_sort	zbp1 promotes lps-induced cell death and il-1β release via rhim-mediated interactions with ripk1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf0689
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ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

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