Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein i...

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Autores principales: Prashanta Silwal, Jin Kyung Kim, Sang Min Jeon, June-Young Lee, Young Jae Kim, Yi Sak Kim, Yeji Seo, Jihye Kim, Soo Yeon Kim, Min Joung Lee, Jun Young Heo, Mi-Ja Jung, Hyun Sik Kim, Dong-Wook Hyun, Jeong Eun Han, Jake Whang, Yang Hoon Huh, Sang-Hee Lee, Won Do Heo, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c241f6f109ee4107a945d04e843f3c45
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spelling oai:doaj.org-article:c241f6f109ee4107a945d04e843f3c452021-12-02T15:36:12ZMitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice10.1038/s42003-021-02073-62399-3642https://doaj.org/article/c241f6f109ee4107a945d04e843f3c452021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02073-6https://doaj.org/toc/2399-3642Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein is involved in host defense against intracellular bacterial infection.Prashanta SilwalJin Kyung KimSang Min JeonJune-Young LeeYoung Jae KimYi Sak KimYeji SeoJihye KimSoo Yeon KimMin Joung LeeJun Young HeoMi-Ja JungHyun Sik KimDong-Wook HyunJeong Eun HanJake WhangYang Hoon HuhSang-Hee LeeWon Do HeoJin-Man KimJin-Woo BaeEun-Kyeong JoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Prashanta Silwal
Jin Kyung Kim
Sang Min Jeon
June-Young Lee
Young Jae Kim
Yi Sak Kim
Yeji Seo
Jihye Kim
Soo Yeon Kim
Min Joung Lee
Jun Young Heo
Mi-Ja Jung
Hyun Sik Kim
Dong-Wook Hyun
Jeong Eun Han
Jake Whang
Yang Hoon Huh
Sang-Hee Lee
Won Do Heo
Jin-Man Kim
Jin-Woo Bae
Eun-Kyeong Jo
Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
description Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein is involved in host defense against intracellular bacterial infection.
format article
author Prashanta Silwal
Jin Kyung Kim
Sang Min Jeon
June-Young Lee
Young Jae Kim
Yi Sak Kim
Yeji Seo
Jihye Kim
Soo Yeon Kim
Min Joung Lee
Jun Young Heo
Mi-Ja Jung
Hyun Sik Kim
Dong-Wook Hyun
Jeong Eun Han
Jake Whang
Yang Hoon Huh
Sang-Hee Lee
Won Do Heo
Jin-Man Kim
Jin-Woo Bae
Eun-Kyeong Jo
author_facet Prashanta Silwal
Jin Kyung Kim
Sang Min Jeon
June-Young Lee
Young Jae Kim
Yi Sak Kim
Yeji Seo
Jihye Kim
Soo Yeon Kim
Min Joung Lee
Jun Young Heo
Mi-Ja Jung
Hyun Sik Kim
Dong-Wook Hyun
Jeong Eun Han
Jake Whang
Yang Hoon Huh
Sang-Hee Lee
Won Do Heo
Jin-Man Kim
Jin-Woo Bae
Eun-Kyeong Jo
author_sort Prashanta Silwal
title Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
title_short Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
title_full Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
title_fullStr Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
title_full_unstemmed Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
title_sort mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c241f6f109ee4107a945d04e843f3c45
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