Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

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Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein i...

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Autores principales:	Prashanta Silwal, Jin Kyung Kim, Sang Min Jeon, June-Young Lee, Young Jae Kim, Yi Sak Kim, Yeji Seo, Jihye Kim, Soo Yeon Kim, Min Joung Lee, Jun Young Heo, Mi-Ja Jung, Hyun Sik Kim, Dong-Wook Hyun, Jeong Eun Han, Jake Whang, Yang Hoon Huh, Sang-Hee Lee, Won Do Heo, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c241f6f109ee4107a945d04e843f3c45
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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