Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations

The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of...

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Autores principales:	Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 glycerophospholipid linoleic acid microbiota SARS-CoV-2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c246775704074acd94da58c98a6a1a4b
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spelling	oai:doaj.org-article:c246775704074acd94da58c98a6a1a4b2021-11-05T16:07:43ZGut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations1664-302X10.3389/fmicb.2021.761067https://doaj.org/article/c246775704074acd94da58c98a6a1a4b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.761067/fullhttps://doaj.org/toc/1664-302XThe interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly beneficial butyrate producers such as Anaerostipes (p-value = 1.75 × 10–230), Lachnospiraceae (p-value = 7.14 × 10–65), and Blautia (p-value = 9.22 × 10–18) in the SARS-CoV-2-infected group in comparison to the control group. Moreover, phylogenetic investigation of communities by reconstructing unobserved state (PICRUSt) functional prediction analysis of the 16S rRNA gene abundance data showed substantial differences in the enrichment of metabolic pathways such as lipid, amino acid, carbohydrate, and xenobiotic metabolism, in comparison between both groups. We discovered an enrichment of linoleic acid, ether lipid, glycerolipid, and glycerophospholipid metabolism in the SARS-CoV-2-infected group, suggesting a link to SARS-CoV-2 entry and replication in host cells. We estimate the major contributing genera to the four pathways to be Parabacteroides, Streptococcus, Dorea, and Blautia, respectively. The identified differences provide a new insight to enrich our understanding of SARS-CoV-2-related changes in gut microbiota, their metabolic capabilities, and potential screening biomarkers linked to COVID-19 disease severity.Mohammad Tahseen Al BatainehMohammad Tahseen Al BatainehMohammad Tahseen Al BatainehMohammad Tahseen Al BatainehAndreas HenschelAndreas HenschelMira MousaMira MousaMarianne DaouFathimathuz WaasiaHussein KannoutMariam KhaliliMohd Azzam KayassehAbdulmajeed AlkhajehMaimunah UddinNawal AlkaabiGuan K. TayGuan K. TaySamuel F. FengSamuel F. FengAhmed F. YousefHabiba S. AlsafarHabiba S. AlsafarHabiba S. AlsafarFrontiers Media S.A.articleCOVID-19glycerophospholipidlinoleic acidmicrobiotaSARS-CoV-2MicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 glycerophospholipid linoleic acid microbiota SARS-CoV-2 Microbiology QR1-502
spellingShingle	COVID-19 glycerophospholipid linoleic acid microbiota SARS-CoV-2 Microbiology QR1-502 Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Andreas Henschel Andreas Henschel Mira Mousa Mira Mousa Marianne Daou Fathimathuz Waasia Hussein Kannout Mariam Khalili Mohd Azzam Kayasseh Abdulmajeed Alkhajeh Maimunah Uddin Nawal Alkaabi Guan K. Tay Guan K. Tay Samuel F. Feng Samuel F. Feng Ahmed F. Yousef Habiba S. Alsafar Habiba S. Alsafar Habiba S. Alsafar Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
description	The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly beneficial butyrate producers such as Anaerostipes (p-value = 1.75 × 10–230), Lachnospiraceae (p-value = 7.14 × 10–65), and Blautia (p-value = 9.22 × 10–18) in the SARS-CoV-2-infected group in comparison to the control group. Moreover, phylogenetic investigation of communities by reconstructing unobserved state (PICRUSt) functional prediction analysis of the 16S rRNA gene abundance data showed substantial differences in the enrichment of metabolic pathways such as lipid, amino acid, carbohydrate, and xenobiotic metabolism, in comparison between both groups. We discovered an enrichment of linoleic acid, ether lipid, glycerolipid, and glycerophospholipid metabolism in the SARS-CoV-2-infected group, suggesting a link to SARS-CoV-2 entry and replication in host cells. We estimate the major contributing genera to the four pathways to be Parabacteroides, Streptococcus, Dorea, and Blautia, respectively. The identified differences provide a new insight to enrich our understanding of SARS-CoV-2-related changes in gut microbiota, their metabolic capabilities, and potential screening biomarkers linked to COVID-19 disease severity.
format	article
author	Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Andreas Henschel Andreas Henschel Mira Mousa Mira Mousa Marianne Daou Fathimathuz Waasia Hussein Kannout Mariam Khalili Mohd Azzam Kayasseh Abdulmajeed Alkhajeh Maimunah Uddin Nawal Alkaabi Guan K. Tay Guan K. Tay Samuel F. Feng Samuel F. Feng Ahmed F. Yousef Habiba S. Alsafar Habiba S. Alsafar Habiba S. Alsafar
author_facet	Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Mohammad Tahseen Al Bataineh Andreas Henschel Andreas Henschel Mira Mousa Mira Mousa Marianne Daou Fathimathuz Waasia Hussein Kannout Mariam Khalili Mohd Azzam Kayasseh Abdulmajeed Alkhajeh Maimunah Uddin Nawal Alkaabi Guan K. Tay Guan K. Tay Samuel F. Feng Samuel F. Feng Ahmed F. Yousef Habiba S. Alsafar Habiba S. Alsafar Habiba S. Alsafar
author_sort	Mohammad Tahseen Al Bataineh
title	Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
title_short	Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
title_full	Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
title_fullStr	Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
title_full_unstemmed	Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations
title_sort	gut microbiota interplay with covid-19 reveals links to host lipid metabolism among middle eastern populations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c246775704074acd94da58c98a6a1a4b
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Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations

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