A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis

Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials. Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond cleavage—that allows mild and high yielding transamida...

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Autores principales:	Emma L. Baker, Michael M. Yamano, Yujing Zhou, Sarah M. Anthony, Neil K. Garg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c246e43ab97345fb9962efe853715b19
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spelling	oai:doaj.org-article:c246e43ab97345fb9962efe853715b192021-12-02T14:40:11ZA two-step approach to achieve secondary amide transamidation enabled by nickel catalysis10.1038/ncomms115542041-1723https://doaj.org/article/c246e43ab97345fb9962efe853715b192016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11554https://doaj.org/toc/2041-1723Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials. Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond cleavage—that allows mild and high yielding transamidation.Emma L. BakerMichael M. YamanoYujing ZhouSarah M. AnthonyNeil K. GargNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma L. Baker Michael M. Yamano Yujing Zhou Sarah M. Anthony Neil K. Garg A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
description	Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials. Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond cleavage—that allows mild and high yielding transamidation.
format	article
author	Emma L. Baker Michael M. Yamano Yujing Zhou Sarah M. Anthony Neil K. Garg
author_facet	Emma L. Baker Michael M. Yamano Yujing Zhou Sarah M. Anthony Neil K. Garg
author_sort	Emma L. Baker
title	A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
title_short	A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
title_full	A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
title_fullStr	A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
title_full_unstemmed	A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
title_sort	two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c246e43ab97345fb9962efe853715b19
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A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis

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