A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis

Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials. Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond cleavage—that allows mild and high yielding transamida...

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Autores principales: Emma L. Baker, Michael M. Yamano, Yujing Zhou, Sarah M. Anthony, Neil K. Garg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c246e43ab97345fb9962efe853715b19
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