Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation

Abstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed D...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sung Uk Baek, Min Seon Park, Bum-Joo Cho, In Won Park, Soonil Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2474812c6764b4280d5bc122f5ffe87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2474812c6764b4280d5bc122f5ffe87
record_format	dspace
spelling	oai:doaj.org-article:c2474812c6764b4280d5bc122f5ffe872021-12-02T15:39:50ZRisk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation10.1038/s41598-021-93384-52045-2322https://doaj.org/article/c2474812c6764b4280d5bc122f5ffe872021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93384-5https://doaj.org/toc/2045-2322Abstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed DR patients who had completed PRP in at least one eye with a 3-year follow-up. A total of 243 eyes of 243 subjects (mean age 52.6 ± 11.6 years) were enrolled. Among them, 52 patients (21.4%) showed progression of DR after PRP (progression group), and the other 191 (78.6%) patients had stable DR (non-progression group). The progression group had higher proportion of proliferative DR (P = 0.019); lower baseline visual acuity (P < 0.001); and higher platelet count (P = 0.048), hemoglobin (P = 0.044), and hematocrit, (P = 0.042) than the non-progression group. In the multivariate logistic regression analysis for progression of DR, baseline visual acuity (HR: 0.053, P < 0.001) and platelet count (HR: 1.215, P = 0.031) were identified as risk factors for progression. Consequently, we propose that patients with low visual acuity or high platelet count are more likely to have progressive DR despite PRP and require careful observation. Also, the evaluation of hemorheological factors including platelet counts before PRP can be considered useful in predicting the prognosis of DR.Sung Uk BaekMin Seon ParkBum-Joo ChoIn Won ParkSoonil KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
description	Abstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed DR patients who had completed PRP in at least one eye with a 3-year follow-up. A total of 243 eyes of 243 subjects (mean age 52.6 ± 11.6 years) were enrolled. Among them, 52 patients (21.4%) showed progression of DR after PRP (progression group), and the other 191 (78.6%) patients had stable DR (non-progression group). The progression group had higher proportion of proliferative DR (P = 0.019); lower baseline visual acuity (P < 0.001); and higher platelet count (P = 0.048), hemoglobin (P = 0.044), and hematocrit, (P = 0.042) than the non-progression group. In the multivariate logistic regression analysis for progression of DR, baseline visual acuity (HR: 0.053, P < 0.001) and platelet count (HR: 1.215, P = 0.031) were identified as risk factors for progression. Consequently, we propose that patients with low visual acuity or high platelet count are more likely to have progressive DR despite PRP and require careful observation. Also, the evaluation of hemorheological factors including platelet counts before PRP can be considered useful in predicting the prognosis of DR.
format	article
author	Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon
author_facet	Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon
author_sort	Sung Uk Baek
title	Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
title_short	Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
title_full	Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
title_fullStr	Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
title_full_unstemmed	Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
title_sort	risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2474812c6764b4280d5bc122f5ffe87
work_keys_str_mv	AT sungukbaek riskfactorsassociatedwithprogressionofdiabeticretinopathyineyestreatedwithpanretinalphotocoagulation AT minseonpark riskfactorsassociatedwithprogressionofdiabeticretinopathyineyestreatedwithpanretinalphotocoagulation AT bumjoocho riskfactorsassociatedwithprogressionofdiabeticretinopathyineyestreatedwithpanretinalphotocoagulation AT inwonpark riskfactorsassociatedwithprogressionofdiabeticretinopathyineyestreatedwithpanretinalphotocoagulation AT soonilkwon riskfactorsassociatedwithprogressionofdiabeticretinopathyineyestreatedwithpanretinalphotocoagulation
_version_	1718385897561391104

Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation

Ejemplares similares