Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions

Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sample-specific ion distributions.

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Detalles Bibliográficos
Autores principales: Boris Sarvin, Shoval Lagziel, Nikita Sarvin, Dzmitry Mukha, Praveen Kumar, Elina Aizenshtein, Tomer Shlomi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c2489466f4664b04acf5985ee64b9758
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Descripción
Sumario:Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sample-specific ion distributions.