Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions

Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sample-specific ion distributions.

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Autores principales:	Boris Sarvin, Shoval Lagziel, Nikita Sarvin, Dzmitry Mukha, Praveen Kumar, Elina Aizenshtein, Tomer Shlomi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2489466f4664b04acf5985ee64b9758
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spelling	oai:doaj.org-article:c2489466f4664b04acf5985ee64b97582021-12-02T17:14:28ZFast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions10.1038/s41467-020-17026-62041-1723https://doaj.org/article/c2489466f4664b04acf5985ee64b97582020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17026-6https://doaj.org/toc/2041-1723Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sample-specific ion distributions.Boris SarvinShoval LagzielNikita SarvinDzmitry MukhaPraveen KumarElina AizenshteinTomer ShlomiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boris Sarvin Shoval Lagziel Nikita Sarvin Dzmitry Mukha Praveen Kumar Elina Aizenshtein Tomer Shlomi Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
description	Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sample-specific ion distributions.
format	article
author	Boris Sarvin Shoval Lagziel Nikita Sarvin Dzmitry Mukha Praveen Kumar Elina Aizenshtein Tomer Shlomi
author_facet	Boris Sarvin Shoval Lagziel Nikita Sarvin Dzmitry Mukha Praveen Kumar Elina Aizenshtein Tomer Shlomi
author_sort	Boris Sarvin
title	Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
title_short	Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
title_full	Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
title_fullStr	Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
title_full_unstemmed	Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
title_sort	fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c2489466f4664b04acf5985ee64b9758
work_keys_str_mv	AT borissarvin fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT shovallagziel fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT nikitasarvin fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT dzmitrymukha fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT praveenkumar fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT elinaaizenshtein fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions AT tomershlomi fastandsensitiveflowinjectionmassspectrometrymetabolomicsbyanalyzingsamplespecificiondistributions
_version_	1718381343311659008

Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions

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