Structural and functional analysis of mRNA export regulation by the nuclear pore complex

The export of mRNA to the cytosol depends on the nuclear pore complex (NPC) and the activation of the helicase DDX19, but their interplay in humans remains poorly understood. Here, the authors present a structural and functional analysis of DDX19 activation, revealing how the human NPC regulates mRN...

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Autores principales:	Daniel H. Lin, Ana R. Correia, Sarah W. Cai, Ferdinand M. Huber, Claudia A. Jette, André Hoelz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c249d83685d0496192421137269032b5
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spelling	oai:doaj.org-article:c249d83685d0496192421137269032b52021-12-02T15:34:27ZStructural and functional analysis of mRNA export regulation by the nuclear pore complex10.1038/s41467-018-04459-32041-1723https://doaj.org/article/c249d83685d0496192421137269032b52018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04459-3https://doaj.org/toc/2041-1723The export of mRNA to the cytosol depends on the nuclear pore complex (NPC) and the activation of the helicase DDX19, but their interplay in humans remains poorly understood. Here, the authors present a structural and functional analysis of DDX19 activation, revealing how the human NPC regulates mRNA export.Daniel H. LinAna R. CorreiaSarah W. CaiFerdinand M. HuberClaudia A. JetteAndré HoelzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel H. Lin Ana R. Correia Sarah W. Cai Ferdinand M. Huber Claudia A. Jette André Hoelz Structural and functional analysis of mRNA export regulation by the nuclear pore complex
description	The export of mRNA to the cytosol depends on the nuclear pore complex (NPC) and the activation of the helicase DDX19, but their interplay in humans remains poorly understood. Here, the authors present a structural and functional analysis of DDX19 activation, revealing how the human NPC regulates mRNA export.
format	article
author	Daniel H. Lin Ana R. Correia Sarah W. Cai Ferdinand M. Huber Claudia A. Jette André Hoelz
author_facet	Daniel H. Lin Ana R. Correia Sarah W. Cai Ferdinand M. Huber Claudia A. Jette André Hoelz
author_sort	Daniel H. Lin
title	Structural and functional analysis of mRNA export regulation by the nuclear pore complex
title_short	Structural and functional analysis of mRNA export regulation by the nuclear pore complex
title_full	Structural and functional analysis of mRNA export regulation by the nuclear pore complex
title_fullStr	Structural and functional analysis of mRNA export regulation by the nuclear pore complex
title_full_unstemmed	Structural and functional analysis of mRNA export regulation by the nuclear pore complex
title_sort	structural and functional analysis of mrna export regulation by the nuclear pore complex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c249d83685d0496192421137269032b5
work_keys_str_mv	AT danielhlin structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex AT anarcorreia structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex AT sarahwcai structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex AT ferdinandmhuber structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex AT claudiaajette structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex AT andrehoelz structuralandfunctionalanalysisofmrnaexportregulationbythenuclearporecomplex
_version_	1718386861878018048

Structural and functional analysis of mRNA export regulation by the nuclear pore complex

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