Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies

Cancer: Key proteins hiding in the neighbourhood Cancer is considered a systems disease in which the interactors of cancer-related proteins have a key role, also as targets to fight cancer. New therapeutic approaches are needed to improve success rates and to identify suitable proteins as novel, alt...

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Autores principales:	Dezső Módos, Krishna C. Bulusu, Dávid Fazekas, János Kubisch, Johanne Brooks, István Marczell, Péter M. Szabó, Tibor Vellai, Péter Csermely, Katalin Lenti, Andreas Bender, Tamás Korcsmáros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c24e96069e4742dbadae90e9d4086c72
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spelling	oai:doaj.org-article:c24e96069e4742dbadae90e9d4086c722021-12-02T12:33:54ZNeighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies10.1038/s41540-017-0003-62056-7189https://doaj.org/article/c24e96069e4742dbadae90e9d4086c722017-01-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0003-6https://doaj.org/toc/2056-7189Cancer: Key proteins hiding in the neighbourhood Cancer is considered a systems disease in which the interactors of cancer-related proteins have a key role, also as targets to fight cancer. New therapeutic approaches are needed to improve success rates and to identify suitable proteins as novel, alternative drug targets. We designed a computational approach, combining mutation and differential expression data with network information, to analyse the interactions of cancer-related proteins in colon, breast, liver and lung cancer. We found that first (direct) neighbours, not linked previously to the given cancer type, are similarly important as mutated proteins known to be involved in cancer development. We found 223 drugs already in the clinic targeting these proteins but not yet used against cancer as their oncology relevance was hidden so far. Our observations open up new strategies for target selection and anti-cancer drug discovery.Dezső MódosKrishna C. BulusuDávid FazekasJános KubischJohanne BrooksIstván MarczellPéter M. SzabóTibor VellaiPéter CsermelyKatalin LentiAndreas BenderTamás KorcsmárosNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Dezső Módos Krishna C. Bulusu Dávid Fazekas János Kubisch Johanne Brooks István Marczell Péter M. Szabó Tibor Vellai Péter Csermely Katalin Lenti Andreas Bender Tamás Korcsmáros Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
description	Cancer: Key proteins hiding in the neighbourhood Cancer is considered a systems disease in which the interactors of cancer-related proteins have a key role, also as targets to fight cancer. New therapeutic approaches are needed to improve success rates and to identify suitable proteins as novel, alternative drug targets. We designed a computational approach, combining mutation and differential expression data with network information, to analyse the interactions of cancer-related proteins in colon, breast, liver and lung cancer. We found that first (direct) neighbours, not linked previously to the given cancer type, are similarly important as mutated proteins known to be involved in cancer development. We found 223 drugs already in the clinic targeting these proteins but not yet used against cancer as their oncology relevance was hidden so far. Our observations open up new strategies for target selection and anti-cancer drug discovery.
format	article
author	Dezső Módos Krishna C. Bulusu Dávid Fazekas János Kubisch Johanne Brooks István Marczell Péter M. Szabó Tibor Vellai Péter Csermely Katalin Lenti Andreas Bender Tamás Korcsmáros
author_facet	Dezső Módos Krishna C. Bulusu Dávid Fazekas János Kubisch Johanne Brooks István Marczell Péter M. Szabó Tibor Vellai Péter Csermely Katalin Lenti Andreas Bender Tamás Korcsmáros
author_sort	Dezső Módos
title	Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
title_short	Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
title_full	Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
title_fullStr	Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
title_full_unstemmed	Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
title_sort	neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c24e96069e4742dbadae90e9d4086c72
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Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies

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