Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

<h4>Background</h4>The endothelin B receptor (ET(B)R) promotes tumorigenesis and melanoma progression through activation by endothelin (ET)-1, thus representing a promising therapeutic target. The stability of hypoxia-inducible factor (HIF)-1alpha is essential for melanomagenesis and pro...

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Main Authors: Francesca Spinella, Laura Rosanò, Martina Del Duca, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c24fb6c15afe43e3b03640a8f22c5992
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https://doaj.org/article/c24fb6c15afe43e3b03640a8f22c5992

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