Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.

<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH). Previous work suggests an association between the Tyr113His and His139Arg mEH polymorphisms and susceptibility to hepatocellu...

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Autores principales:	Jian-Hong Zhong, Bang-De Xiang, Liang Ma, Xue-Mei You, Le-Qun Li, Gui-Sheng Xie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c250e51936894037acd33e5d1594fe8f
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spelling	oai:doaj.org-article:c250e51936894037acd33e5d1594fe8f2021-11-18T07:56:08ZMeta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.1932-620310.1371/journal.pone.0057064https://doaj.org/article/c250e51936894037acd33e5d1594fe8f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451147/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH). Previous work suggests an association between the Tyr113His and His139Arg mEH polymorphisms and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent.<h4>Methods</h4>PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between Tyr113His and His139Arg mEH polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Eleven studies were included in the meta-analysis, involving 1,696 HCC cases and 3,600 controls. The 113His- mEH allele was significantly associated with increased risk of HCC based on allelic contrast (OR = 1.35, 95% CI = 1.04-1.75, p = 0.02), homozygote comparison (OR = 1.65, 95% CI = 1.07-2.54, p = 0.02) and a recessive genetic model (OR = 1.54, 95% CI = 1.21-1.96, p<0.001), while individuals carrying the Arg139Arg mEH genotype had no association with increased or decreased risk of HCC.<h4>Conclusion</h4>The 113His- allele polymorphism in mEH may be a risk factor for hepatocarcinogenesis, while the mEH 139Arg- allele may not be a risk or protective factor. There is substantial evidence that mEH polymorphisms interact synergistically with other genes and the environment to modulate risk of HCC. Further large and well-designed studies are needed to confirm these conclusions.Jian-Hong ZhongBang-De XiangLiang MaXue-Mei YouLe-Qun LiGui-Sheng XiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57064 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Hong Zhong Bang-De Xiang Liang Ma Xue-Mei You Le-Qun Li Gui-Sheng Xie Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
description	<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH). Previous work suggests an association between the Tyr113His and His139Arg mEH polymorphisms and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent.<h4>Methods</h4>PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between Tyr113His and His139Arg mEH polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Eleven studies were included in the meta-analysis, involving 1,696 HCC cases and 3,600 controls. The 113His- mEH allele was significantly associated with increased risk of HCC based on allelic contrast (OR = 1.35, 95% CI = 1.04-1.75, p = 0.02), homozygote comparison (OR = 1.65, 95% CI = 1.07-2.54, p = 0.02) and a recessive genetic model (OR = 1.54, 95% CI = 1.21-1.96, p<0.001), while individuals carrying the Arg139Arg mEH genotype had no association with increased or decreased risk of HCC.<h4>Conclusion</h4>The 113His- allele polymorphism in mEH may be a risk factor for hepatocarcinogenesis, while the mEH 139Arg- allele may not be a risk or protective factor. There is substantial evidence that mEH polymorphisms interact synergistically with other genes and the environment to modulate risk of HCC. Further large and well-designed studies are needed to confirm these conclusions.
format	article
author	Jian-Hong Zhong Bang-De Xiang Liang Ma Xue-Mei You Le-Qun Li Gui-Sheng Xie
author_facet	Jian-Hong Zhong Bang-De Xiang Liang Ma Xue-Mei You Le-Qun Li Gui-Sheng Xie
author_sort	Jian-Hong Zhong
title	Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
title_short	Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
title_full	Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
title_fullStr	Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
title_full_unstemmed	Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
title_sort	meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c250e51936894037acd33e5d1594fe8f
work_keys_str_mv	AT jianhongzhong metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma AT bangdexiang metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma AT liangma metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma AT xuemeiyou metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma AT lequnli metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma AT guishengxie metaanalysisofmicrosomalepoxidehydrolasegenepolymorphismandriskofhepatocellularcarcinoma
_version_	1718422755238477824

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.

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