Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory

Abstract Past evidence suggests that hippocampal subregions, namely the anterior and posterior parts, may be engaged in distinct networks underlying the memory functions which may be altered in patients with schizophrenia. However, of the very few studies that have investigated the hippocampal longi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jules R. Dugré, Alexandre Dumais, Andras Tikasz, Adriana Mendrek, Stéphane Potvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/c254c730d7094162b8ad95224659b438
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c254c730d7094162b8ad95224659b438
record_format	dspace
spelling	oai:doaj.org-article:c254c730d7094162b8ad95224659b4382021-12-02T13:33:05ZFunctional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory10.1038/s41537-021-00147-22334-265Xhttps://doaj.org/article/c254c730d7094162b8ad95224659b4382021-03-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00147-2https://doaj.org/toc/2334-265XAbstract Past evidence suggests that hippocampal subregions, namely the anterior and posterior parts, may be engaged in distinct networks underlying the memory functions which may be altered in patients with schizophrenia. However, of the very few studies that have investigated the hippocampal longitudinal axis subdivisions functional connectivity in patients with schizophrenia, the majority was based on resting-state data, and yet, none aimed to examine these during an episodic memory task. A total of 41 patients with schizophrenia and 45 healthy controls were recruited for a magnetic resonance imaging protocol in which they performed an explicit memory task. Seed-based functional connectivity analysis was employed to assess connectivity abnormalities between hippocampal subregions and voxel-wise connectivity targets in patients with schizophrenia. We observed a significantly reduced connectivity between the posterior hippocampus and regions from the default mode network, but increased connectivity with the primary visual cortex, in patients with schizophrenia compared to healthy subjects. Increased connectivity between the anterior hippocampus and anterior temporal regions also characterized patients with schizophrenia. In the current study, we provided evidence and support for studying hippocampal subdivisions along the longitudinal axis in schizophrenia. Our results suggest that the abnormalities in hippocampal subregions functional connectivity reflect deficits in episodic memory that may be implicated in the pathophysiology of schizophrenia.Jules R. DugréAlexandre DumaisAndras TikaszAdriana MendrekStéphane PotvinNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Jules R. Dugré Alexandre Dumais Andras Tikasz Adriana Mendrek Stéphane Potvin Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
description	Abstract Past evidence suggests that hippocampal subregions, namely the anterior and posterior parts, may be engaged in distinct networks underlying the memory functions which may be altered in patients with schizophrenia. However, of the very few studies that have investigated the hippocampal longitudinal axis subdivisions functional connectivity in patients with schizophrenia, the majority was based on resting-state data, and yet, none aimed to examine these during an episodic memory task. A total of 41 patients with schizophrenia and 45 healthy controls were recruited for a magnetic resonance imaging protocol in which they performed an explicit memory task. Seed-based functional connectivity analysis was employed to assess connectivity abnormalities between hippocampal subregions and voxel-wise connectivity targets in patients with schizophrenia. We observed a significantly reduced connectivity between the posterior hippocampus and regions from the default mode network, but increased connectivity with the primary visual cortex, in patients with schizophrenia compared to healthy subjects. Increased connectivity between the anterior hippocampus and anterior temporal regions also characterized patients with schizophrenia. In the current study, we provided evidence and support for studying hippocampal subdivisions along the longitudinal axis in schizophrenia. Our results suggest that the abnormalities in hippocampal subregions functional connectivity reflect deficits in episodic memory that may be implicated in the pathophysiology of schizophrenia.
format	article
author	Jules R. Dugré Alexandre Dumais Andras Tikasz Adriana Mendrek Stéphane Potvin
author_facet	Jules R. Dugré Alexandre Dumais Andras Tikasz Adriana Mendrek Stéphane Potvin
author_sort	Jules R. Dugré
title	Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
title_short	Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
title_full	Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
title_fullStr	Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
title_full_unstemmed	Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
title_sort	functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c254c730d7094162b8ad95224659b438
work_keys_str_mv	AT julesrdugre functionalconnectivityabnormalitiesofthelongaxishippocampalsubregionsinschizophreniaduringepisodicmemory AT alexandredumais functionalconnectivityabnormalitiesofthelongaxishippocampalsubregionsinschizophreniaduringepisodicmemory AT andrastikasz functionalconnectivityabnormalitiesofthelongaxishippocampalsubregionsinschizophreniaduringepisodicmemory AT adrianamendrek functionalconnectivityabnormalitiesofthelongaxishippocampalsubregionsinschizophreniaduringepisodicmemory AT stephanepotvin functionalconnectivityabnormalitiesofthelongaxishippocampalsubregionsinschizophreniaduringepisodicmemory
_version_	1718392880816455680

Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory

Ejemplares similares