Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study

Heng Liu,1,* Hua Chen,1,* Bo Wu,1 Tijiang Zhang,1 Jinhui Wang,2,3 Kexin Huang,1 Ganjun Song,1 Jian Zhan4 1Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, Guizhou, 2Department of Psychology, Hangzhou Normal University, 3Zhe...

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Autores principales:	Liu H, Chen H, Wu B, Zhang TJ, Wang J, Huang KX, Song GJ, Zhan J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	multiple sclerosis amplitude of low frequency fluctuation receiver operating characteristic functional magnetic resonance imaging blood oxygen level-dependent resting-state. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c255f551e9bd4a7a8d65d939d6bda654
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spelling	oai:doaj.org-article:c255f551e9bd4a7a8d65d939d6bda6542021-12-02T07:42:28ZFunctional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study1178-2021https://doaj.org/article/c255f551e9bd4a7a8d65d939d6bda6542016-11-01T00:00:00Zhttps://www.dovepress.com/functional-cortical-changes-in-relapsing-remitting-multiple-sclerosis--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Heng Liu,1,* Hua Chen,1,* Bo Wu,1 Tijiang Zhang,1 Jinhui Wang,2,3 Kexin Huang,1 Ganjun Song,1 Jian Zhan4 1Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, Guizhou, 2Department of Psychology, Hangzhou Normal University, 3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, 4Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing–remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method. Methods: ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score. Patients and participants: A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study. Measurements and results: Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (r=-0.474, P=0.047). Conclusion: RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS. Keywords: multiple sclerosis, amplitude of low-frequency fluctuation, receiver operating characteristic, functional magnetic resonance imaging, blood oxygen level dependent, resting stateLiu HChen HWu BZhang TJWang JHuang KXSong GJZhan JDove Medical Pressarticlemultiple sclerosisamplitude of low frequency fluctuationreceiver operating characteristicfunctional magnetic resonance imagingblood oxygen level-dependentresting-state.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3031-3039 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis amplitude of low frequency fluctuation receiver operating characteristic functional magnetic resonance imaging blood oxygen level-dependent resting-state. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	multiple sclerosis amplitude of low frequency fluctuation receiver operating characteristic functional magnetic resonance imaging blood oxygen level-dependent resting-state. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu H Chen H Wu B Zhang TJ Wang J Huang KX Song GJ Zhan J Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
description	Heng Liu,1,* Hua Chen,1,* Bo Wu,1 Tijiang Zhang,1 Jinhui Wang,2,3 Kexin Huang,1 Ganjun Song,1 Jian Zhan4 1Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, Guizhou, 2Department of Psychology, Hangzhou Normal University, 3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, 4Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing–remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method. Methods: ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score. Patients and participants: A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study. Measurements and results: Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (r=-0.474, P=0.047). Conclusion: RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS. Keywords: multiple sclerosis, amplitude of low-frequency fluctuation, receiver operating characteristic, functional magnetic resonance imaging, blood oxygen level dependent, resting state
format	article
author	Liu H Chen H Wu B Zhang TJ Wang J Huang KX Song GJ Zhan J
author_facet	Liu H Chen H Wu B Zhang TJ Wang J Huang KX Song GJ Zhan J
author_sort	Liu H
title	Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
title_short	Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
title_full	Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
title_fullStr	Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
title_full_unstemmed	Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
title_sort	functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fmri study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c255f551e9bd4a7a8d65d939d6bda654
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Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study

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