Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.

The widespread insecticide resistance raises concerns for vector control implementation and sustainability particularly for the control of the main vector of human malaria, Anopheles gambiae sensu stricto. However, the extent to which insecticide resistance mechanisms interfere with the development...

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Autores principales:	Haoues Alout, Nicaise Tuikue Ndam, Marcel Maurice Sandeu, Innocent Djégbe, Fabrice Chandre, Roch Kounbobr Dabiré, Luc Salako Djogbénou, Vincent Corbel, Anna Cohuet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c257089e8c624c53aa882de525b1fac3
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spelling	oai:doaj.org-article:c257089e8c624c53aa882de525b1fac32021-11-18T07:44:53ZInsecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.1932-620310.1371/journal.pone.0063849https://doaj.org/article/c257089e8c624c53aa882de525b1fac32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23704944/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The widespread insecticide resistance raises concerns for vector control implementation and sustainability particularly for the control of the main vector of human malaria, Anopheles gambiae sensu stricto. However, the extent to which insecticide resistance mechanisms interfere with the development of the malignant malaria parasite in its vector and their impact on overall malaria transmission remains unknown. We explore the impact of insecticide resistance on the outcome of Plasmodium falciparum infection in its natural vector using three An. gambiae strains sharing a common genetic background, one susceptible to insecticides and two resistant, one homozygous for the ace-1(R) mutation and one for the kdr mutation. Experimental infections of the three strains were conducted in parallel with field isolates of P. falciparum from Burkina Faso (West Africa) by direct membrane feeding assays. Both insecticide resistant mutations influence the outcome of malaria infection by increasing the prevalence of infection. In contrast, the kdr resistant allele is associated with reduced parasite burden in infected individuals at the oocyst stage, when compared to the susceptible strain, while the ace-1 (R) resistant allele showing no such association. Thus insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards P. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes. These results are of great concern for the epidemiology of malaria considering the widespread pyrethroid resistance currently observed in Sub-Saharan Africa and the efforts deployed to control the disease.Haoues AloutNicaise Tuikue NdamMarcel Maurice SandeuInnocent DjégbeFabrice ChandreRoch Kounbobr DabiréLuc Salako DjogbénouVincent CorbelAnna CohuetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63849 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haoues Alout Nicaise Tuikue Ndam Marcel Maurice Sandeu Innocent Djégbe Fabrice Chandre Roch Kounbobr Dabiré Luc Salako Djogbénou Vincent Corbel Anna Cohuet Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
description	The widespread insecticide resistance raises concerns for vector control implementation and sustainability particularly for the control of the main vector of human malaria, Anopheles gambiae sensu stricto. However, the extent to which insecticide resistance mechanisms interfere with the development of the malignant malaria parasite in its vector and their impact on overall malaria transmission remains unknown. We explore the impact of insecticide resistance on the outcome of Plasmodium falciparum infection in its natural vector using three An. gambiae strains sharing a common genetic background, one susceptible to insecticides and two resistant, one homozygous for the ace-1(R) mutation and one for the kdr mutation. Experimental infections of the three strains were conducted in parallel with field isolates of P. falciparum from Burkina Faso (West Africa) by direct membrane feeding assays. Both insecticide resistant mutations influence the outcome of malaria infection by increasing the prevalence of infection. In contrast, the kdr resistant allele is associated with reduced parasite burden in infected individuals at the oocyst stage, when compared to the susceptible strain, while the ace-1 (R) resistant allele showing no such association. Thus insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards P. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes. These results are of great concern for the epidemiology of malaria considering the widespread pyrethroid resistance currently observed in Sub-Saharan Africa and the efforts deployed to control the disease.
format	article
author	Haoues Alout Nicaise Tuikue Ndam Marcel Maurice Sandeu Innocent Djégbe Fabrice Chandre Roch Kounbobr Dabiré Luc Salako Djogbénou Vincent Corbel Anna Cohuet
author_facet	Haoues Alout Nicaise Tuikue Ndam Marcel Maurice Sandeu Innocent Djégbe Fabrice Chandre Roch Kounbobr Dabiré Luc Salako Djogbénou Vincent Corbel Anna Cohuet
author_sort	Haoues Alout
title	Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
title_short	Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
title_full	Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
title_fullStr	Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
title_full_unstemmed	Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.
title_sort	insecticide resistance alleles affect vector competence of anopheles gambiae s.s. for plasmodium falciparum field isolates.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c257089e8c624c53aa882de525b1fac3
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Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates.

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