Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality

Abstract Dendritic spines change their size and shape spontaneously, but the function of this remains unclear. Here, we address this in a biophysical model of spine fluctuations, which reproduces experimentally measured spine fluctuations. For this, we characterize size- and shape fluctuations from...

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Autores principales:	Mayte Bonilla-Quintana, Florentin Wörgötter, Elisa D’Este, Christian Tetzlaff, Michael Fauth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c25e43ba1518463789679b3c4d2888e1
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spelling	oai:doaj.org-article:c25e43ba1518463789679b3c4d2888e12021-12-02T14:04:39ZReproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality10.1038/s41598-021-83331-92045-2322https://doaj.org/article/c25e43ba1518463789679b3c4d2888e12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83331-9https://doaj.org/toc/2045-2322Abstract Dendritic spines change their size and shape spontaneously, but the function of this remains unclear. Here, we address this in a biophysical model of spine fluctuations, which reproduces experimentally measured spine fluctuations. For this, we characterize size- and shape fluctuations from confocal microscopy image sequences using autoregressive models and a new set of shape descriptors derived from circular statistics. Using the biophysical model, we extrapolate into longer temporal intervals and find the presence of 1/f noise. When investigating its origins, the model predicts that the actin dynamics underlying shape fluctuations self-organizes into a critical state, which creates a fine balance between static actin filaments and free monomers. In a comparison against a non-critical model, we show that this state facilitates spine enlargement, which happens after LTP induction. Thus, ongoing spine shape fluctuations might be necessary to react quickly to plasticity events.Mayte Bonilla-QuintanaFlorentin WörgötterElisa D’EsteChristian TetzlaffMichael FauthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayte Bonilla-Quintana Florentin Wörgötter Elisa D’Este Christian Tetzlaff Michael Fauth Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
description	Abstract Dendritic spines change their size and shape spontaneously, but the function of this remains unclear. Here, we address this in a biophysical model of spine fluctuations, which reproduces experimentally measured spine fluctuations. For this, we characterize size- and shape fluctuations from confocal microscopy image sequences using autoregressive models and a new set of shape descriptors derived from circular statistics. Using the biophysical model, we extrapolate into longer temporal intervals and find the presence of 1/f noise. When investigating its origins, the model predicts that the actin dynamics underlying shape fluctuations self-organizes into a critical state, which creates a fine balance between static actin filaments and free monomers. In a comparison against a non-critical model, we show that this state facilitates spine enlargement, which happens after LTP induction. Thus, ongoing spine shape fluctuations might be necessary to react quickly to plasticity events.
format	article
author	Mayte Bonilla-Quintana Florentin Wörgötter Elisa D’Este Christian Tetzlaff Michael Fauth
author_facet	Mayte Bonilla-Quintana Florentin Wörgötter Elisa D’Este Christian Tetzlaff Michael Fauth
author_sort	Mayte Bonilla-Quintana
title	Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
title_short	Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
title_full	Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
title_fullStr	Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
title_full_unstemmed	Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
title_sort	reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c25e43ba1518463789679b3c4d2888e1
work_keys_str_mv	AT maytebonillaquintana reproducingasymmetricalspineshapefluctuationsinamodelofactindynamicspredictsselforganizedcriticality AT florentinworgotter reproducingasymmetricalspineshapefluctuationsinamodelofactindynamicspredictsselforganizedcriticality AT elisadeste reproducingasymmetricalspineshapefluctuationsinamodelofactindynamicspredictsselforganizedcriticality AT christiantetzlaff reproducingasymmetricalspineshapefluctuationsinamodelofactindynamicspredictsselforganizedcriticality AT michaelfauth reproducingasymmetricalspineshapefluctuationsinamodelofactindynamicspredictsselforganizedcriticality
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Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality

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