Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy

Abstract People often experience high level of distress during invasive interventions, which may exceed their coping abilities. This may be in particular evident when confronted with the suspicion of cancer. Taking the example of prostate biopsy sampling, we aimed at investigating the impact of an M...

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Autores principales:	Nils Kohn, Jan Heidkamp, Guillén Fernández, Jurgen Fütterer, Indira Tendolkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c264da8e819f4123a23ce3f66a6feab3
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spelling	oai:doaj.org-article:c264da8e819f4123a23ce3f66a6feab32021-12-02T13:57:37ZMeasuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy10.1038/s41598-021-82199-z2045-2322https://doaj.org/article/c264da8e819f4123a23ce3f66a6feab32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82199-zhttps://doaj.org/toc/2045-2322Abstract People often experience high level of distress during invasive interventions, which may exceed their coping abilities. This may be in particular evident when confronted with the suspicion of cancer. Taking the example of prostate biopsy sampling, we aimed at investigating the impact of an MRI guided prostate biopsy on the acute stress response and its mechanistic basis. We recruited 20 men with a clinical suspicion of prostate cancer. Immediately before an MRI guided biopsy procedure, we conducted fMRI in the same scanner to assess resting-state brain connectivity. Physiological and hormonal stress measures were taken during the procedure and associated with questionnaires, hair cortisol levels and brain measures to elucidate mechanistic factors for elevated stress. As expected, patients reported a stress-related change in affect. Decreased positive affect was associated with higher hair but not saliva cortisol concentration. Stronger use of maladaptive emotion regulation techniques, elevated depression scores and higher within-salience-network connectivity was associated with stronger increase in negative affect and/or decrease of positive affect during the procedure. While being limited in its generalization due to age, sample size and gender, our proof of concept study demonstrates the utility of real-life stressors and large-scale brain network measures in stress regulation research with potential impact in clinical practice.Nils KohnJan HeidkampGuillén FernándezJurgen FüttererIndira TendolkarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nils Kohn Jan Heidkamp Guillén Fernández Jurgen Fütterer Indira Tendolkar Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
description	Abstract People often experience high level of distress during invasive interventions, which may exceed their coping abilities. This may be in particular evident when confronted with the suspicion of cancer. Taking the example of prostate biopsy sampling, we aimed at investigating the impact of an MRI guided prostate biopsy on the acute stress response and its mechanistic basis. We recruited 20 men with a clinical suspicion of prostate cancer. Immediately before an MRI guided biopsy procedure, we conducted fMRI in the same scanner to assess resting-state brain connectivity. Physiological and hormonal stress measures were taken during the procedure and associated with questionnaires, hair cortisol levels and brain measures to elucidate mechanistic factors for elevated stress. As expected, patients reported a stress-related change in affect. Decreased positive affect was associated with higher hair but not saliva cortisol concentration. Stronger use of maladaptive emotion regulation techniques, elevated depression scores and higher within-salience-network connectivity was associated with stronger increase in negative affect and/or decrease of positive affect during the procedure. While being limited in its generalization due to age, sample size and gender, our proof of concept study demonstrates the utility of real-life stressors and large-scale brain network measures in stress regulation research with potential impact in clinical practice.
format	article
author	Nils Kohn Jan Heidkamp Guillén Fernández Jurgen Fütterer Indira Tendolkar
author_facet	Nils Kohn Jan Heidkamp Guillén Fernández Jurgen Fütterer Indira Tendolkar
author_sort	Nils Kohn
title	Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
title_short	Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
title_full	Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
title_fullStr	Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
title_full_unstemmed	Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy
title_sort	measuring inter-individual differences in stress sensitivity during mr-guided prostate biopsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c264da8e819f4123a23ce3f66a6feab3
work_keys_str_mv	AT nilskohn measuringinterindividualdifferencesinstresssensitivityduringmrguidedprostatebiopsy AT janheidkamp measuringinterindividualdifferencesinstresssensitivityduringmrguidedprostatebiopsy AT guillenfernandez measuringinterindividualdifferencesinstresssensitivityduringmrguidedprostatebiopsy AT jurgenfutterer measuringinterindividualdifferencesinstresssensitivityduringmrguidedprostatebiopsy AT indiratendolkar measuringinterindividualdifferencesinstresssensitivityduringmrguidedprostatebiopsy
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Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy

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