Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine

Cocaine addiction is accompanied by dysfunction in neural circuits related to reward, but it is unclear how these adaptations occur. Here, authors identify granulocyte-colony stimulating factor as a potent mediator of cocaine-induced adaptations, and show that it can alter the motivation for cocaine...

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Bibliographic Details
Main Authors: Erin S. Calipari, Arthur Godino, Emily G. Peck, Marine Salery, Nicholas L. Mervosh, Joseph A. Landry, Scott J. Russo, Yasmin L. Hurd, Eric J. Nestler, Drew D. Kiraly
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/c2650a6a7cc84e57a9b370118f9135cd
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Summary:Cocaine addiction is accompanied by dysfunction in neural circuits related to reward, but it is unclear how these adaptations occur. Here, authors identify granulocyte-colony stimulating factor as a potent mediator of cocaine-induced adaptations, and show that it can alter the motivation for cocaine.