Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.

Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1 infected patients. However, the quantitative contribution of the several potential mechanisms of action of IL-7 is unknown. We have performed a mathematical an...

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Autores principales:	Rodolphe Thiébaut, Julia Drylewicz, Mélanie Prague, Christine Lacabaratz, Stéphanie Beq, Ana Jarne, Thérèse Croughs, Rafick-Pierre Sekaly, Michael M Lederman, Irini Sereti, Daniel Commenges, Yves Lévy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c2686c9e352e4e8a8a992c7f7a8d279d
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spelling	oai:doaj.org-article:c2686c9e352e4e8a8a992c7f7a8d279d2021-11-11T05:52:09ZQuantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.1553-734X1553-735810.1371/journal.pcbi.1003630https://doaj.org/article/c2686c9e352e4e8a8a992c7f7a8d279d2014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24853554/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1 infected patients. However, the quantitative contribution of the several potential mechanisms of action of IL-7 is unknown. We have performed a mathematical analysis of repeated measurements of total and naive CD4+ T cells and their Ki67 expression from HIV-1 infected patients involved in three phase I/II studies (N = 53 patients). We show that, besides a transient increase of peripheral proliferation, IL-7 exerts additional effects that play a significant role in CD4+ T cell dynamics up to 52 weeks. A decrease of the loss rate of the total CD4+ T cell is the most probable explanation. If this effect could be maintained during repeated administration of IL-7, our simulation study shows that such a strategy may allow maintaining CD4+ T cell counts above 500 cells/µL with 4 cycles or fewer over a period of two years. This in-depth analysis of clinical data revealed the potential for IL-7 to achieve sustained CD4+ T cell restoration with limited IL-7 exposure in HIV-1 infected patients with immune failure despite antiretroviral therapy.Rodolphe ThiébautJulia DrylewiczMélanie PragueChristine LacabaratzStéphanie BeqAna JarneThérèse CroughsRafick-Pierre SekalyMichael M LedermanIrini SeretiDaniel CommengesYves LévyPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 5, p e1003630 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rodolphe Thiébaut Julia Drylewicz Mélanie Prague Christine Lacabaratz Stéphanie Beq Ana Jarne Thérèse Croughs Rafick-Pierre Sekaly Michael M Lederman Irini Sereti Daniel Commenges Yves Lévy Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
description	Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1 infected patients. However, the quantitative contribution of the several potential mechanisms of action of IL-7 is unknown. We have performed a mathematical analysis of repeated measurements of total and naive CD4+ T cells and their Ki67 expression from HIV-1 infected patients involved in three phase I/II studies (N = 53 patients). We show that, besides a transient increase of peripheral proliferation, IL-7 exerts additional effects that play a significant role in CD4+ T cell dynamics up to 52 weeks. A decrease of the loss rate of the total CD4+ T cell is the most probable explanation. If this effect could be maintained during repeated administration of IL-7, our simulation study shows that such a strategy may allow maintaining CD4+ T cell counts above 500 cells/µL with 4 cycles or fewer over a period of two years. This in-depth analysis of clinical data revealed the potential for IL-7 to achieve sustained CD4+ T cell restoration with limited IL-7 exposure in HIV-1 infected patients with immune failure despite antiretroviral therapy.
format	article
author	Rodolphe Thiébaut Julia Drylewicz Mélanie Prague Christine Lacabaratz Stéphanie Beq Ana Jarne Thérèse Croughs Rafick-Pierre Sekaly Michael M Lederman Irini Sereti Daniel Commenges Yves Lévy
author_facet	Rodolphe Thiébaut Julia Drylewicz Mélanie Prague Christine Lacabaratz Stéphanie Beq Ana Jarne Thérèse Croughs Rafick-Pierre Sekaly Michael M Lederman Irini Sereti Daniel Commenges Yves Lévy
author_sort	Rodolphe Thiébaut
title	Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
title_short	Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
title_full	Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
title_fullStr	Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
title_full_unstemmed	Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
title_sort	quantifying and predicting the effect of exogenous interleukin-7 on cd4+ t cells in hiv-1 infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c2686c9e352e4e8a8a992c7f7a8d279d
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Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.

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