The natural history of biocatalytic mechanisms.

Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently showed that the α/β architecture is probably the oldest fold design. This holds important implications for the origins of biochemistry. Here we explore structure-function relationships addressing the u...

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Bibliographic Details
Main Authors: Neetika Nath, John B O Mitchell, Gustavo Caetano-Anollés
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
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Online Access:https://doaj.org/article/c269b62b51b74a46a42cd6459169997b
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