The natural history of biocatalytic mechanisms.
Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently showed that the α/β architecture is probably the oldest fold design. This holds important implications for the origins of biochemistry. Here we explore structure-function relationships addressing the u...
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Main Authors: | Neetika Nath, John B O Mitchell, Gustavo Caetano-Anollés |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2014
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Online Access: | https://doaj.org/article/c269b62b51b74a46a42cd6459169997b |
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