Decreased activity in the reward network of chronic insomnia patients

Abstract In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional sti...

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Autores principales:	Yuki Motomura, Ruri Katsunuma, Naoko Ayabe, Kentaro Oba, Yuri Terasawa, Shingo Kitamura, Yoshiya Moriguchi, Akiko Hida, Yuichi Kamei, Kazuo Mishima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c26c6dc43ac049b4842af96232ce131f
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spelling	oai:doaj.org-article:c26c6dc43ac049b4842af96232ce131f2021-12-02T14:27:02ZDecreased activity in the reward network of chronic insomnia patients10.1038/s41598-020-79989-22045-2322https://doaj.org/article/c26c6dc43ac049b4842af96232ce131f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79989-2https://doaj.org/toc/2045-2322Abstract In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.Yuki MotomuraRuri KatsunumaNaoko AyabeKentaro ObaYuri TerasawaShingo KitamuraYoshiya MoriguchiAkiko HidaYuichi KameiKazuo MishimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuki Motomura Ruri Katsunuma Naoko Ayabe Kentaro Oba Yuri Terasawa Shingo Kitamura Yoshiya Moriguchi Akiko Hida Yuichi Kamei Kazuo Mishima Decreased activity in the reward network of chronic insomnia patients
description	Abstract In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.
format	article
author	Yuki Motomura Ruri Katsunuma Naoko Ayabe Kentaro Oba Yuri Terasawa Shingo Kitamura Yoshiya Moriguchi Akiko Hida Yuichi Kamei Kazuo Mishima
author_facet	Yuki Motomura Ruri Katsunuma Naoko Ayabe Kentaro Oba Yuri Terasawa Shingo Kitamura Yoshiya Moriguchi Akiko Hida Yuichi Kamei Kazuo Mishima
author_sort	Yuki Motomura
title	Decreased activity in the reward network of chronic insomnia patients
title_short	Decreased activity in the reward network of chronic insomnia patients
title_full	Decreased activity in the reward network of chronic insomnia patients
title_fullStr	Decreased activity in the reward network of chronic insomnia patients
title_full_unstemmed	Decreased activity in the reward network of chronic insomnia patients
title_sort	decreased activity in the reward network of chronic insomnia patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c26c6dc43ac049b4842af96232ce131f
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Decreased activity in the reward network of chronic insomnia patients

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