Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammato...

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Autores principales:	Niyati Desai, Azfar Neyaz, Annamaria Szabolcs, Angela R. Shih, Jonathan H. Chen, Vishal Thapar, Linda T. Nieman, Alexander Solovyov, Arnav Mehta, David J. Lieb, Anupriya S. Kulkarni, Christopher Jaicks, Katherine H. Xu, Michael J. Raabe, Christopher J. Pinto, Dejan Juric, Ivan Chebib, Robert B. Colvin, Arthur Y. Kim, Robert Monroe, Sarah E. Warren, Patrick Danaher, Jason W. Reeves, Jingjing Gong, Erroll H. Rueckert, Benjamin D. Greenbaum, Nir Hacohen, Stephen M. Lagana, Miguel N. Rivera, Lynette M. Sholl, James R. Stone, David T. Ting, Vikram Deshpande
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c26ed9e652d143d4a25413482e8fff81
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id	oai:doaj.org-article:c26ed9e652d143d4a25413482e8fff81
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spelling	oai:doaj.org-article:c26ed9e652d143d4a25413482e8fff812021-12-02T10:48:10ZTemporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection10.1038/s41467-020-20139-72041-1723https://doaj.org/article/c26ed9e652d143d4a25413482e8fff812020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20139-7https://doaj.org/toc/2041-1723Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage.Niyati DesaiAzfar NeyazAnnamaria SzabolcsAngela R. ShihJonathan H. ChenVishal ThaparLinda T. NiemanAlexander SolovyovArnav MehtaDavid J. LiebAnupriya S. KulkarniChristopher JaicksKatherine H. XuMichael J. RaabeChristopher J. PintoDejan JuricIvan ChebibRobert B. ColvinArthur Y. KimRobert MonroeSarah E. WarrenPatrick DanaherJason W. ReevesJingjing GongErroll H. RueckertBenjamin D. GreenbaumNir HacohenStephen M. LaganaMiguel N. RiveraLynette M. ShollJames R. StoneDavid T. TingVikram DeshpandeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niyati Desai Azfar Neyaz Annamaria Szabolcs Angela R. Shih Jonathan H. Chen Vishal Thapar Linda T. Nieman Alexander Solovyov Arnav Mehta David J. Lieb Anupriya S. Kulkarni Christopher Jaicks Katherine H. Xu Michael J. Raabe Christopher J. Pinto Dejan Juric Ivan Chebib Robert B. Colvin Arthur Y. Kim Robert Monroe Sarah E. Warren Patrick Danaher Jason W. Reeves Jingjing Gong Erroll H. Rueckert Benjamin D. Greenbaum Nir Hacohen Stephen M. Lagana Miguel N. Rivera Lynette M. Sholl James R. Stone David T. Ting Vikram Deshpande Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
description	Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage.
format	article
author	Niyati Desai Azfar Neyaz Annamaria Szabolcs Angela R. Shih Jonathan H. Chen Vishal Thapar Linda T. Nieman Alexander Solovyov Arnav Mehta David J. Lieb Anupriya S. Kulkarni Christopher Jaicks Katherine H. Xu Michael J. Raabe Christopher J. Pinto Dejan Juric Ivan Chebib Robert B. Colvin Arthur Y. Kim Robert Monroe Sarah E. Warren Patrick Danaher Jason W. Reeves Jingjing Gong Erroll H. Rueckert Benjamin D. Greenbaum Nir Hacohen Stephen M. Lagana Miguel N. Rivera Lynette M. Sholl James R. Stone David T. Ting Vikram Deshpande
author_facet	Niyati Desai Azfar Neyaz Annamaria Szabolcs Angela R. Shih Jonathan H. Chen Vishal Thapar Linda T. Nieman Alexander Solovyov Arnav Mehta David J. Lieb Anupriya S. Kulkarni Christopher Jaicks Katherine H. Xu Michael J. Raabe Christopher J. Pinto Dejan Juric Ivan Chebib Robert B. Colvin Arthur Y. Kim Robert Monroe Sarah E. Warren Patrick Danaher Jason W. Reeves Jingjing Gong Erroll H. Rueckert Benjamin D. Greenbaum Nir Hacohen Stephen M. Lagana Miguel N. Rivera Lynette M. Sholl James R. Stone David T. Ting Vikram Deshpande
author_sort	Niyati Desai
title	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
title_short	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
title_full	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
title_fullStr	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
title_full_unstemmed	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
title_sort	temporal and spatial heterogeneity of host response to sars-cov-2 pulmonary infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c26ed9e652d143d4a25413482e8fff81
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Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

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