Yersinia pestis: new evidence for an old infection.

The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research. The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the...

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Autores principales:	Kirsten I Bos, Philip Stevens, Kay Nieselt, Hendrik N Poinar, Sharon N Dewitte, Johannes Krause
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c270f1f63e3644f9806838ca3dbf1a80
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spelling	oai:doaj.org-article:c270f1f63e3644f9806838ca3dbf1a802021-11-18T08:07:18ZYersinia pestis: new evidence for an old infection.1932-620310.1371/journal.pone.0049803https://doaj.org/article/c270f1f63e3644f9806838ca3dbf1a802012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209603/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research. The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the level of genetic diversity represented in modern genomic sequences that are publicly accessible, and the paucity of available complete genomes restricts the level of phylogenetic resolution that can be obtained. Here we add to our original analysis of the Yersinia pestis strain implicated in the Black Death by consolidating our dataset for 18 modern genomes with single nucleotide polymorphism (SNP) data for an additional 289 strains at over 600 positions. The inclusion of this additional data reveals a cluster of Y. pestis strains that diverge at a time significantly in advance of the Black Death, with divergence dates roughly coincident with the Plague of Justinian (6(th) to 8(th) century AD). In addition, the analysis reveals further clues regarding potential radiation events that occurred immediately preceding the Black Death, and the legacy it may have left in modern Y. pestis populations. This work reiterates the need for more publicly available complete genomes, both modern and ancient, to achieve an accurate understanding of the history of this bacterium.Kirsten I BosPhilip StevensKay NieseltHendrik N PoinarSharon N DewitteJohannes KrausePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49803 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirsten I Bos Philip Stevens Kay Nieselt Hendrik N Poinar Sharon N Dewitte Johannes Krause Yersinia pestis: new evidence for an old infection.
description	The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research. The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the level of genetic diversity represented in modern genomic sequences that are publicly accessible, and the paucity of available complete genomes restricts the level of phylogenetic resolution that can be obtained. Here we add to our original analysis of the Yersinia pestis strain implicated in the Black Death by consolidating our dataset for 18 modern genomes with single nucleotide polymorphism (SNP) data for an additional 289 strains at over 600 positions. The inclusion of this additional data reveals a cluster of Y. pestis strains that diverge at a time significantly in advance of the Black Death, with divergence dates roughly coincident with the Plague of Justinian (6(th) to 8(th) century AD). In addition, the analysis reveals further clues regarding potential radiation events that occurred immediately preceding the Black Death, and the legacy it may have left in modern Y. pestis populations. This work reiterates the need for more publicly available complete genomes, both modern and ancient, to achieve an accurate understanding of the history of this bacterium.
format	article
author	Kirsten I Bos Philip Stevens Kay Nieselt Hendrik N Poinar Sharon N Dewitte Johannes Krause
author_facet	Kirsten I Bos Philip Stevens Kay Nieselt Hendrik N Poinar Sharon N Dewitte Johannes Krause
author_sort	Kirsten I Bos
title	Yersinia pestis: new evidence for an old infection.
title_short	Yersinia pestis: new evidence for an old infection.
title_full	Yersinia pestis: new evidence for an old infection.
title_fullStr	Yersinia pestis: new evidence for an old infection.
title_full_unstemmed	Yersinia pestis: new evidence for an old infection.
title_sort	yersinia pestis: new evidence for an old infection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c270f1f63e3644f9806838ca3dbf1a80
work_keys_str_mv	AT kirstenibos yersiniapestisnewevidenceforanoldinfection AT philipstevens yersiniapestisnewevidenceforanoldinfection AT kaynieselt yersiniapestisnewevidenceforanoldinfection AT hendriknpoinar yersiniapestisnewevidenceforanoldinfection AT sharonndewitte yersiniapestisnewevidenceforanoldinfection AT johanneskrause yersiniapestisnewevidenceforanoldinfection
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Yersinia pestis: new evidence for an old infection.

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