Insights from engraftable immunodeficient mouse models of hyperinsulinaemia

Abstract Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 −/−) suitable for engraftment with human-derived tissue xenogra...

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Main Authors: Michelle L. Maugham, Patrick B. Thomas, Gabrielle J. Crisp, Lisa K. Philp, Esha T. Shah, Adrian C. Herington, Chen Chen, Laura S. Gregory, Colleen C. Nelson, Inge Seim, Penny L. Jeffery, Lisa K. Chopin
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/c2713d5fce7f4465a1a7d3cfce80dd7e
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