Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease
Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochem...
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Endocrinology Research Centre
2009
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oai:doaj.org-article:c2715a984cfc45a0a704c028f45ac9aa2021-11-14T09:00:14ZMarkers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease2072-03512072-037810.14341/2072-0351-5711https://doaj.org/article/c2715a984cfc45a0a704c028f45ac9aa2009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5711https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochemical, genetic, and immunological examination. Results. Those with the ?classical? onset of DM1 had significantly fewer CD95-expressing lymphocytes and more CD95L+ lymphocytes than control subjects. Carriers of genes responsible for high risk of DM1 showed especially large number of lymphocytes expressing CD95L. Conclusion. It is conjectured that DM1 is characterized by the suppression of mechanism controlling apoptosis of activated lymphocytes that may promote prolongation of the immune response.Elena Vladimirovna PekarevaTatiana Vasil'evna NikonovaVera Anatol'evna GorelyshevaYana Stanislavovna ZverevaSvetlana Mikhailovna StepanovaSergey Alexandrovich Prokof'evOlga Mikhailovna SmirnovaEndocrinology Research Centrearticletype 1 diabetes mellitusapoptosiscd95cd95lcd95cd95lNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 73-89 (2009) |
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DOAJ |
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EN RU |
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type 1 diabetes mellitus apoptosis cd95 cd95l cd95 cd95l Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
type 1 diabetes mellitus apoptosis cd95 cd95l cd95 cd95l Nutritional diseases. Deficiency diseases RC620-627 Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| description |
Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochemical, genetic, and immunological examination. Results. Those with the ?classical? onset of DM1 had significantly fewer CD95-expressing lymphocytes and more CD95L+ lymphocytes than control subjects. Carriers of genes responsible for high risk of DM1 showed especially large number of lymphocytes expressing CD95L. Conclusion. It is conjectured that DM1 is characterized by the suppression of mechanism controlling apoptosis of activated lymphocytes that may promote prolongation of the immune response. |
| format |
article |
| author |
Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova |
| author_facet |
Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova |
| author_sort |
Elena Vladimirovna Pekareva |
| title |
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_short |
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_full |
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_fullStr |
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_full_unstemmed |
Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_sort |
markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| publisher |
Endocrinology Research Centre |
| publishDate |
2009 |
| url |
https://doaj.org/article/c2715a984cfc45a0a704c028f45ac9aa |
| work_keys_str_mv |
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