Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane regio...

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Autores principales: Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M. Dreyfuss, Brian T. O’Neill, Alfred K. Ramirez, Hui Pan, Jonathon N. Winnay, Jeremie Boucher, Michael J. Eck, C. Ronald Kahn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b3
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spelling oai:doaj.org-article:c27316e5cd6942f09a89e65936cda8b32021-12-02T17:06:11ZDomain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression10.1038/ncomms148922041-1723https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b32017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14892https://doaj.org/toc/2041-1723Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.Weikang CaiMasaji SakaguchiAndre KleinriddersGonzalo Gonzalez-Del PinoJonathan M. DreyfussBrian T. O’NeillAlfred K. RamirezHui PanJonathon N. WinnayJeremie BoucherMichael J. EckC. Ronald KahnNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weikang Cai
Masaji Sakaguchi
Andre Kleinridders
Gonzalo Gonzalez-Del Pino
Jonathan M. Dreyfuss
Brian T. O’Neill
Alfred K. Ramirez
Hui Pan
Jonathon N. Winnay
Jeremie Boucher
Michael J. Eck
C. Ronald Kahn
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
description Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.
format article
author Weikang Cai
Masaji Sakaguchi
Andre Kleinridders
Gonzalo Gonzalez-Del Pino
Jonathan M. Dreyfuss
Brian T. O’Neill
Alfred K. Ramirez
Hui Pan
Jonathon N. Winnay
Jeremie Boucher
Michael J. Eck
C. Ronald Kahn
author_facet Weikang Cai
Masaji Sakaguchi
Andre Kleinridders
Gonzalo Gonzalez-Del Pino
Jonathan M. Dreyfuss
Brian T. O’Neill
Alfred K. Ramirez
Hui Pan
Jonathon N. Winnay
Jeremie Boucher
Michael J. Eck
C. Ronald Kahn
author_sort Weikang Cai
title Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
title_short Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
title_full Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
title_fullStr Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
title_full_unstemmed Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
title_sort domain-dependent effects of insulin and igf-1 receptors on signalling and gene expression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b3
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AT masajisakaguchi domaindependenteffectsofinsulinandigf1receptorsonsignallingandgeneexpression
AT andrekleinridders domaindependenteffectsofinsulinandigf1receptorsonsignallingandgeneexpression
AT gonzalogonzalezdelpino domaindependenteffectsofinsulinandigf1receptorsonsignallingandgeneexpression
AT jonathanmdreyfuss domaindependenteffectsofinsulinandigf1receptorsonsignallingandgeneexpression
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