Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane regio...

Full description

Saved in:
Bibliographic Details
Main Authors: Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M. Dreyfuss, Brian T. O’Neill, Alfred K. Ramirez, Hui Pan, Jonathon N. Winnay, Jeremie Boucher, Michael J. Eck, C. Ronald Kahn
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b3

Similar Items