RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart

Abstract Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is higher during the day in the human (anticipating incre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanwen Wang, Cali Anderson, Halina Dobrzynski, George Hart, Alicia D’Souza, Mark R. Boyett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c273968fb8c84a61a1ba8904335d6d83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c273968fb8c84a61a1ba8904335d6d83
record_format	dspace
spelling	oai:doaj.org-article:c273968fb8c84a61a1ba8904335d6d832021-12-02T14:26:54ZRNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart10.1038/s41598-021-82202-72045-2322https://doaj.org/article/c273968fb8c84a61a1ba8904335d6d832021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82202-7https://doaj.org/toc/2045-2322Abstract Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is higher during the day in the human (anticipating increased day-time demand). Although this is attributed to a day-night rhythm in post-translational ion channel regulation in the heart’s pacemaker, the sinus node, by the autonomic nervous system, we investigated whether there is a day-night rhythm in transcription. RNAseq revealed that ~ 44% of the sinus node transcriptome (7134 of 16,387 transcripts) has a significant day-night rhythm. The data revealed the oscillating components of an intrinsic circadian clock. Presumably this clock (or perhaps the master circadian clock in the suprachiasmatic nucleus) is responsible for the rhythm observed in the transcriptional machinery, which in turn is responsible for the rhythm observed in the transcriptome. For example, there is a rhythm in transcripts responsible for the two principal pacemaker mechanisms (membrane and Ca2+ clocks), transcripts responsible for receptors and signalling pathways known to control pacemaking, transcripts from genes identified by GWAS as determinants of resting heart rate, and transcripts from genes responsible for familial and acquired sick sinus syndrome.Yanwen WangCali AndersonHalina DobrzynskiGeorge HartAlicia D’SouzaMark R. BoyettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanwen Wang Cali Anderson Halina Dobrzynski George Hart Alicia D’Souza Mark R. Boyett RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
description	Abstract Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is higher during the day in the human (anticipating increased day-time demand). Although this is attributed to a day-night rhythm in post-translational ion channel regulation in the heart’s pacemaker, the sinus node, by the autonomic nervous system, we investigated whether there is a day-night rhythm in transcription. RNAseq revealed that ~ 44% of the sinus node transcriptome (7134 of 16,387 transcripts) has a significant day-night rhythm. The data revealed the oscillating components of an intrinsic circadian clock. Presumably this clock (or perhaps the master circadian clock in the suprachiasmatic nucleus) is responsible for the rhythm observed in the transcriptional machinery, which in turn is responsible for the rhythm observed in the transcriptome. For example, there is a rhythm in transcripts responsible for the two principal pacemaker mechanisms (membrane and Ca2+ clocks), transcripts responsible for receptors and signalling pathways known to control pacemaking, transcripts from genes identified by GWAS as determinants of resting heart rate, and transcripts from genes responsible for familial and acquired sick sinus syndrome.
format	article
author	Yanwen Wang Cali Anderson Halina Dobrzynski George Hart Alicia D’Souza Mark R. Boyett
author_facet	Yanwen Wang Cali Anderson Halina Dobrzynski George Hart Alicia D’Souza Mark R. Boyett
author_sort	Yanwen Wang
title	RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
title_short	RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
title_full	RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
title_fullStr	RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
title_full_unstemmed	RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
title_sort	rnaseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c273968fb8c84a61a1ba8904335d6d83
work_keys_str_mv	AT yanwenwang rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart AT calianderson rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart AT halinadobrzynski rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart AT georgehart rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart AT aliciadsouza rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart AT markrboyett rnaseqshowsanallpervasivedaynightrhythminthetranscriptomeofthepacemakeroftheheart
_version_	1718391335866597376

RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart

Ejemplares similares