Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression

Abstract The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various i...

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Autores principales:	Natsuko Saito-Sasaki, Yu Sawada, Emi Mashima, Takashi Yamaguchi, Shun Ohmori, Haruna Yoshioka, Sanehito Haruyama, Etsuko Okada, Motonobu Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2748112d5144559995d02d8385bb8d9
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spelling	oai:doaj.org-article:c2748112d5144559995d02d8385bb8d92021-12-02T15:07:51ZMaresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression10.1038/s41598-018-23623-92045-2322https://doaj.org/article/c2748112d5144559995d02d8385bb8d92018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23623-9https://doaj.org/toc/2045-2322Abstract The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammatory disease models. However, the effect of topical MaR1 on cutaneous inflammation remains unclear. Therefore, we initially examined the anti-inflammatory effects of topical Maresin-1 using an imiquimod (IMQ)-induced psoriasis-like mouse model of inflammation. Topical MaR1 reduced the ear swelling response as seen in histological findings. RT-PCR and flow cytometry analyses revealed MaR1 had no inhibitory effect on IL-23, but MaR1 suppressed IL-17A production by γδTCRmid+ and CD4+ cells in the skin. These inhibitory effects were also observed in a subcutaneous IL-23-injected psoriasis model. MaR1 downmodulated IL-23 receptor (IL-23R) expression by suppressing retinoic acid-related orphan receptor γt (RORγt) expression and internalization in a clathrin-dependent manner in γδTCRmid+ and CD4+ cells. These results lead to assumptions that topical MaR1 may be a new therapeutic agent for psoriasis and other IL-17-mediated cutaneous inflammatory diseases.Natsuko Saito-SasakiYu SawadaEmi MashimaTakashi YamaguchiShun OhmoriHaruna YoshiokaSanehito HaruyamaEtsuko OkadaMotonobu NakamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natsuko Saito-Sasaki Yu Sawada Emi Mashima Takashi Yamaguchi Shun Ohmori Haruna Yoshioka Sanehito Haruyama Etsuko Okada Motonobu Nakamura Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
description	Abstract The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammatory disease models. However, the effect of topical MaR1 on cutaneous inflammation remains unclear. Therefore, we initially examined the anti-inflammatory effects of topical Maresin-1 using an imiquimod (IMQ)-induced psoriasis-like mouse model of inflammation. Topical MaR1 reduced the ear swelling response as seen in histological findings. RT-PCR and flow cytometry analyses revealed MaR1 had no inhibitory effect on IL-23, but MaR1 suppressed IL-17A production by γδTCRmid+ and CD4+ cells in the skin. These inhibitory effects were also observed in a subcutaneous IL-23-injected psoriasis model. MaR1 downmodulated IL-23 receptor (IL-23R) expression by suppressing retinoic acid-related orphan receptor γt (RORγt) expression and internalization in a clathrin-dependent manner in γδTCRmid+ and CD4+ cells. These results lead to assumptions that topical MaR1 may be a new therapeutic agent for psoriasis and other IL-17-mediated cutaneous inflammatory diseases.
format	article
author	Natsuko Saito-Sasaki Yu Sawada Emi Mashima Takashi Yamaguchi Shun Ohmori Haruna Yoshioka Sanehito Haruyama Etsuko Okada Motonobu Nakamura
author_facet	Natsuko Saito-Sasaki Yu Sawada Emi Mashima Takashi Yamaguchi Shun Ohmori Haruna Yoshioka Sanehito Haruyama Etsuko Okada Motonobu Nakamura
author_sort	Natsuko Saito-Sasaki
title	Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
title_short	Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
title_full	Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
title_fullStr	Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
title_full_unstemmed	Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
title_sort	maresin-1 suppresses imiquimod-induced skin inflammation by regulating il-23 receptor expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c2748112d5144559995d02d8385bb8d9
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Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression

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