Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.

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Autores principales:	Daniel S. Leventhal, Anna Sokolovska, Ning Li, Christopher Plescia, Starsha A. Kolodziej, Carey W. Gallant, Rudy Christmas, Jian-Rong Gao, Michael J. James, Andres Abin-Fuentes, Munira Momin, Christopher Bergeron, Adam Fisher, Paul F. Miller, Kip A. West, Jose M. Lora
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c274837c940442a5b5b9051d086275aa
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spelling	oai:doaj.org-article:c274837c940442a5b5b9051d086275aa2021-12-02T18:24:58ZImmunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity10.1038/s41467-020-16602-02041-1723https://doaj.org/article/c274837c940442a5b5b9051d086275aa2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16602-0https://doaj.org/toc/2041-1723Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.Daniel S. LeventhalAnna SokolovskaNing LiChristopher PlesciaStarsha A. KolodziejCarey W. GallantRudy ChristmasJian-Rong GaoMichael J. JamesAndres Abin-FuentesMunira MominChristopher BergeronAdam FisherPaul F. MillerKip A. WestJose M. LoraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel S. Leventhal Anna Sokolovska Ning Li Christopher Plescia Starsha A. Kolodziej Carey W. Gallant Rudy Christmas Jian-Rong Gao Michael J. James Andres Abin-Fuentes Munira Momin Christopher Bergeron Adam Fisher Paul F. Miller Kip A. West Jose M. Lora Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
description	Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.
format	article
author	Daniel S. Leventhal Anna Sokolovska Ning Li Christopher Plescia Starsha A. Kolodziej Carey W. Gallant Rudy Christmas Jian-Rong Gao Michael J. James Andres Abin-Fuentes Munira Momin Christopher Bergeron Adam Fisher Paul F. Miller Kip A. West Jose M. Lora
author_facet	Daniel S. Leventhal Anna Sokolovska Ning Li Christopher Plescia Starsha A. Kolodziej Carey W. Gallant Rudy Christmas Jian-Rong Gao Michael J. James Andres Abin-Fuentes Munira Momin Christopher Bergeron Adam Fisher Paul F. Miller Kip A. West Jose M. Lora
author_sort	Daniel S. Leventhal
title	Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
title_short	Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
title_full	Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
title_fullStr	Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
title_full_unstemmed	Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
title_sort	immunotherapy with engineered bacteria by targeting the sting pathway for anti-tumor immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c274837c940442a5b5b9051d086275aa
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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

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