Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease

Bacterial infections contribute to accelerated progression and severity of chronic obstructive pulmonary disease (COPD). Apples have been associated with reduced symptoms of COPD and disease development due to their polyphenolic content. We examined if phloretin, an apple polyphenol, could inhibit b...

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Autores principales:	Rahel L. Birru, Kiflai Bein, Natalya Bondarchuk, Heather Wells, Qiao Lin, Y. Peter Di, George D. Leikauf
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bacteria phloretin antibacterial anti-inflammatory neutrophil COPD Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c275396338c84690accb4415177b20fa
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spelling	oai:doaj.org-article:c275396338c84690accb4415177b20fa2021-11-22T06:35:19ZAntimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease2235-298810.3389/fcimb.2021.652944https://doaj.org/article/c275396338c84690accb4415177b20fa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.652944/fullhttps://doaj.org/toc/2235-2988Bacterial infections contribute to accelerated progression and severity of chronic obstructive pulmonary disease (COPD). Apples have been associated with reduced symptoms of COPD and disease development due to their polyphenolic content. We examined if phloretin, an apple polyphenol, could inhibit bacterial growth and inflammation induced by the main pathogens associated with COPD. Phloretin displayed bacteriostatic and anti-biofilm activity against nontypeable Haemophilus influenzae (NTHi), Moraxella catarrhalis, Streptococcus pneumoniae, and to a lesser extent, Pseudomonas aeruginosa. In vitro, phloretin inhibited NTHi adherence to NCI-H292 cells, a respiratory epithelial cell line. Phloretin also exhibited anti-inflammatory activity in COPD pathogen-induced RAW 264.7 macrophages and human bronchial epithelial cells derived from normal and COPD diseased lungs. In mice, NTHi bacterial load and chemokine (C-X-C motif) ligand 1 (CXCL1), a neutrophil chemoattractant, was attenuated by a diet supplemented with phloretin. Our data suggests that phloretin is a promising antimicrobial and anti-inflammatory nutraceutical for reducing bacterial-induced injury in COPD.Rahel L. BirruKiflai BeinNatalya BondarchukHeather WellsQiao LinY. Peter DiGeorge D. LeikaufFrontiers Media S.A.articlebacteriaphloretinantibacterialanti-inflammatoryneutrophilCOPDMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteria phloretin antibacterial anti-inflammatory neutrophil COPD Microbiology QR1-502
spellingShingle	bacteria phloretin antibacterial anti-inflammatory neutrophil COPD Microbiology QR1-502 Rahel L. Birru Kiflai Bein Natalya Bondarchuk Heather Wells Qiao Lin Y. Peter Di George D. Leikauf Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
description	Bacterial infections contribute to accelerated progression and severity of chronic obstructive pulmonary disease (COPD). Apples have been associated with reduced symptoms of COPD and disease development due to their polyphenolic content. We examined if phloretin, an apple polyphenol, could inhibit bacterial growth and inflammation induced by the main pathogens associated with COPD. Phloretin displayed bacteriostatic and anti-biofilm activity against nontypeable Haemophilus influenzae (NTHi), Moraxella catarrhalis, Streptococcus pneumoniae, and to a lesser extent, Pseudomonas aeruginosa. In vitro, phloretin inhibited NTHi adherence to NCI-H292 cells, a respiratory epithelial cell line. Phloretin also exhibited anti-inflammatory activity in COPD pathogen-induced RAW 264.7 macrophages and human bronchial epithelial cells derived from normal and COPD diseased lungs. In mice, NTHi bacterial load and chemokine (C-X-C motif) ligand 1 (CXCL1), a neutrophil chemoattractant, was attenuated by a diet supplemented with phloretin. Our data suggests that phloretin is a promising antimicrobial and anti-inflammatory nutraceutical for reducing bacterial-induced injury in COPD.
format	article
author	Rahel L. Birru Kiflai Bein Natalya Bondarchuk Heather Wells Qiao Lin Y. Peter Di George D. Leikauf
author_facet	Rahel L. Birru Kiflai Bein Natalya Bondarchuk Heather Wells Qiao Lin Y. Peter Di George D. Leikauf
author_sort	Rahel L. Birru
title	Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
title_short	Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
title_full	Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
title_fullStr	Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease
title_sort	antimicrobial and anti-inflammatory activity of apple polyphenol phloretin on respiratory pathogens associated with chronic obstructive pulmonary disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c275396338c84690accb4415177b20fa
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Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease

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