Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus

Savino Bruno1, Daniela Savojardo1, Piero L Almasio2, Mario U Mondelli31Liver Unit, Department of Medicine, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy; 2Unit&agrave; Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy; 3Struttura Complessa L...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bruno S, Savojardo D, Almasio PL, Mondelli MU
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/c277ff8ee319479881ebd2272f8c599f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c277ff8ee319479881ebd2272f8c599f
record_format	dspace
spelling	oai:doaj.org-article:c277ff8ee319479881ebd2272f8c599f2021-12-02T04:59:35ZCritical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus1179-1535https://doaj.org/article/c277ff8ee319479881ebd2272f8c599f2011-03-01T00:00:00Zhttp://www.dovepress.com/critical-reappraisal-of-risk-factors-for-occurrence-of-hepatocellular--a6891https://doaj.org/toc/1179-1535Savino Bruno1, Daniela Savojardo1, Piero L Almasio2, Mario U Mondelli31Liver Unit, Department of Medicine, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy; 2Unit&agrave; Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy; 3Struttura Complessa Laboratori di Infettivologia, Dipartimento di Malattie Infettive, Fondazione IRCCS Policlinico San Matteo e Universit&agrave; di Pavia, Pavia, ItalyAbstract: More than one and half of current cases of hepatocellular carcinoma in the US, Europe, and Japan are attributable to hepatitis C virus (HCV) infection. HCV is also the primary cause of death in patients with HCV-related cirrhosis, with annual incidences of 0.5%&ndash;5% in Europe and 4%&ndash;10% in Asia. Screening is based on serum alpha-fetoprotein determination and liver ultrasound scan, but the sensitivity of the former is far less than optimal, and screening intervals are still poorly defined for the latter. Risk factors related to the host or environment, or both, appear to be more relevant than viral factors, such as HCV genotype, in determining disease progression to cirrhosis and cancer, and include age, male gender, severity of liver disease at presentation, coinfection with hepatitis B virus or human immunodeficiency virus, and alcohol abuse. Early liver transplantation in selected cases can be curative, but most patients are not eligible for liver grafting and are treated with locoregional ablative therapies, after which recurrence is common. Recently, orally available inhibitors of the vascular endothelial growth factor receptor have shown a significant, albeit modest, increment of survival in patients with advanced hepatocellular carcinoma, thus paving the way for modern molecular approaches to treatment of this highly malignant tumor.Keywords: hepatocellular carcinoma, hepatitis C virus&nbsp; Bruno SSavojardo DAlmasio PLMondelli MUDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2011, Iss default, Pp 21-28 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Bruno S Savojardo D Almasio PL Mondelli MU Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
description	Savino Bruno1, Daniela Savojardo1, Piero L Almasio2, Mario U Mondelli31Liver Unit, Department of Medicine, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy; 2Unit&agrave; Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy; 3Struttura Complessa Laboratori di Infettivologia, Dipartimento di Malattie Infettive, Fondazione IRCCS Policlinico San Matteo e Universit&agrave; di Pavia, Pavia, ItalyAbstract: More than one and half of current cases of hepatocellular carcinoma in the US, Europe, and Japan are attributable to hepatitis C virus (HCV) infection. HCV is also the primary cause of death in patients with HCV-related cirrhosis, with annual incidences of 0.5%&ndash;5% in Europe and 4%&ndash;10% in Asia. Screening is based on serum alpha-fetoprotein determination and liver ultrasound scan, but the sensitivity of the former is far less than optimal, and screening intervals are still poorly defined for the latter. Risk factors related to the host or environment, or both, appear to be more relevant than viral factors, such as HCV genotype, in determining disease progression to cirrhosis and cancer, and include age, male gender, severity of liver disease at presentation, coinfection with hepatitis B virus or human immunodeficiency virus, and alcohol abuse. Early liver transplantation in selected cases can be curative, but most patients are not eligible for liver grafting and are treated with locoregional ablative therapies, after which recurrence is common. Recently, orally available inhibitors of the vascular endothelial growth factor receptor have shown a significant, albeit modest, increment of survival in patients with advanced hepatocellular carcinoma, thus paving the way for modern molecular approaches to treatment of this highly malignant tumor.Keywords: hepatocellular carcinoma, hepatitis C virus&nbsp;
format	article
author	Bruno S Savojardo D Almasio PL Mondelli MU
author_facet	Bruno S Savojardo D Almasio PL Mondelli MU
author_sort	Bruno S
title	Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
title_short	Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
title_full	Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
title_fullStr	Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
title_full_unstemmed	Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus
title_sort	critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis c virus
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/c277ff8ee319479881ebd2272f8c599f
work_keys_str_mv	AT brunos criticalreappraisalofriskfactorsforoccurrenceofhepatocellularcarcinomainpatientswithhepatitiscvirus AT savojardod criticalreappraisalofriskfactorsforoccurrenceofhepatocellularcarcinomainpatientswithhepatitiscvirus AT almasiopl criticalreappraisalofriskfactorsforoccurrenceofhepatocellularcarcinomainpatientswithhepatitiscvirus AT mondellimu criticalreappraisalofriskfactorsforoccurrenceofhepatocellularcarcinomainpatientswithhepatitiscvirus
_version_	1718400916396179456

Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus

Ejemplares similares