Atheroprotective Effects and Molecular Mechanism of Berberine

Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration...

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Autores principales:	Lu Xing, Xin Zhou, Ai-Hong Li, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Li Zhu, Hui-Ling Cao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	atherosclerosis berberine molecular mechanism cell targets gut microbiota Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c2781799081c48a98d2f3d26c3088c29
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spelling	oai:doaj.org-article:c2781799081c48a98d2f3d26c3088c292021-11-16T07:46:12ZAtheroprotective Effects and Molecular Mechanism of Berberine2296-889X10.3389/fmolb.2021.762673https://doaj.org/article/c2781799081c48a98d2f3d26c3088c292021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/fullhttps://doaj.org/toc/2296-889XCardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management.Lu XingXin ZhouAi-Hong LiHui-Jin LiChun-Xia HeWei QinDong ZhaoPeng-Quan LiLi ZhuHui-Ling CaoHui-Ling CaoFrontiers Media S.A.articleatherosclerosisberberinemolecular mechanismcell targetsgut microbiotaBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis berberine molecular mechanism cell targets gut microbiota Biology (General) QH301-705.5
spellingShingle	atherosclerosis berberine molecular mechanism cell targets gut microbiota Biology (General) QH301-705.5 Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao Atheroprotective Effects and Molecular Mechanism of Berberine
description	Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management.
format	article
author	Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao
author_facet	Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao
author_sort	Lu Xing
title	Atheroprotective Effects and Molecular Mechanism of Berberine
title_short	Atheroprotective Effects and Molecular Mechanism of Berberine
title_full	Atheroprotective Effects and Molecular Mechanism of Berberine
title_fullStr	Atheroprotective Effects and Molecular Mechanism of Berberine
title_full_unstemmed	Atheroprotective Effects and Molecular Mechanism of Berberine
title_sort	atheroprotective effects and molecular mechanism of berberine
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c2781799081c48a98d2f3d26c3088c29
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_version_	1718426631167541248

Atheroprotective Effects and Molecular Mechanism of Berberine

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