Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia

Abstract Emphysema-like-change of lung is one aspect of lung morbidity in children after congenital diaphragmatic hernia (CDH). This study aims to evaluate if the extent of reduced lung density can be quantified through pediatric chest CT examinations, if side differences are present and if emphysem...

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Autores principales:	Timm Stoll-Dannenhauer, Gregor Schwab, Katrin Zahn, Thomas Schaible, Lucas Wessel, Christel Weiss, Stefan O. Schoenberg, Thomas Henzler, Meike Weis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c278d92f5d954b1ba5a4d213f37a9b67
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spelling	oai:doaj.org-article:c278d92f5d954b1ba5a4d213f37a9b672021-12-02T15:53:02ZComputed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia10.1038/s41598-021-84623-w2045-2322https://doaj.org/article/c278d92f5d954b1ba5a4d213f37a9b672021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84623-whttps://doaj.org/toc/2045-2322Abstract Emphysema-like-change of lung is one aspect of lung morbidity in children after congenital diaphragmatic hernia (CDH). This study aims to evaluate if the extent of reduced lung density can be quantified through pediatric chest CT examinations, if side differences are present and if emphysema-like tissue is more prominent after CDH than in controls. Thirty-seven chest CT scans of CDH patients (mean age 4.5 ± 4.0 years) were analyzed semi-automatically and compared to an age-matched control group. Emphysema-like-change was defined as areas of lung density lower than − 950 HU in percentage (low attenuating volume, LAV). A p-value lower than 0.05 was regarded as statistically significant. Hypoattenuating lung tissue was more frequently present in the ipsilateral lung than the contralateral side (LAV 12.6% vs. 5.7%; p < 0.0001). While neither ipsilateral nor contralateral lung volume differed between CDH and control (p > 0.05), LAV in ipsilateral (p = 0.0002), but not in contralateral lung (p = 0.54), was higher in CDH than control. It is feasible to quantify emphysema-like-change in pediatric patients after CDH. In the ipsilateral lung, low-density areas are much more frequently present both in comparison to contralateral and to controls. Especially the ratio of LAV ipsilateral/contralateral seems promising as a quantitative parameter in the follow-up after CDH.Timm Stoll-DannenhauerGregor SchwabKatrin ZahnThomas SchaibleLucas WesselChristel WeissStefan O. SchoenbergThomas HenzlerMeike WeisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timm Stoll-Dannenhauer Gregor Schwab Katrin Zahn Thomas Schaible Lucas Wessel Christel Weiss Stefan O. Schoenberg Thomas Henzler Meike Weis Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
description	Abstract Emphysema-like-change of lung is one aspect of lung morbidity in children after congenital diaphragmatic hernia (CDH). This study aims to evaluate if the extent of reduced lung density can be quantified through pediatric chest CT examinations, if side differences are present and if emphysema-like tissue is more prominent after CDH than in controls. Thirty-seven chest CT scans of CDH patients (mean age 4.5 ± 4.0 years) were analyzed semi-automatically and compared to an age-matched control group. Emphysema-like-change was defined as areas of lung density lower than − 950 HU in percentage (low attenuating volume, LAV). A p-value lower than 0.05 was regarded as statistically significant. Hypoattenuating lung tissue was more frequently present in the ipsilateral lung than the contralateral side (LAV 12.6% vs. 5.7%; p < 0.0001). While neither ipsilateral nor contralateral lung volume differed between CDH and control (p > 0.05), LAV in ipsilateral (p = 0.0002), but not in contralateral lung (p = 0.54), was higher in CDH than control. It is feasible to quantify emphysema-like-change in pediatric patients after CDH. In the ipsilateral lung, low-density areas are much more frequently present both in comparison to contralateral and to controls. Especially the ratio of LAV ipsilateral/contralateral seems promising as a quantitative parameter in the follow-up after CDH.
format	article
author	Timm Stoll-Dannenhauer Gregor Schwab Katrin Zahn Thomas Schaible Lucas Wessel Christel Weiss Stefan O. Schoenberg Thomas Henzler Meike Weis
author_facet	Timm Stoll-Dannenhauer Gregor Schwab Katrin Zahn Thomas Schaible Lucas Wessel Christel Weiss Stefan O. Schoenberg Thomas Henzler Meike Weis
author_sort	Timm Stoll-Dannenhauer
title	Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
title_short	Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
title_full	Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
title_fullStr	Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
title_full_unstemmed	Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
title_sort	computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c278d92f5d954b1ba5a4d213f37a9b67
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Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia

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