Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation.

Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. In the present study, we performed a comparative genomic analys...

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Bibliographic Details
Main Authors: Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
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Online Access:https://doaj.org/article/c278e779c81a487ebacd9f1d601ef7d4
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