Novel approach to pathophysiology of type 2 diabetes mellitus
In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance...
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Endocrinology Research Centre
2013
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oai:doaj.org-article:c27ad7942a704513b503d3618588a6ae2021-11-14T09:00:18ZNovel approach to pathophysiology of type 2 diabetes mellitus2072-03512072-037810.14341/DM2013449-51https://doaj.org/article/c27ad7942a704513b503d3618588a6ae2013-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6283https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance during the absorption period. We also discuss the effects on energy homeostasis exercised by cytokines via mTOR pathway (the key factor of insulin signalling) considering the phenomenon of insulin resistance.Emil' Kopeevich MukhamedzhanovOleg Viktorovich EsyrevEndocrinology Research Centrearticletype 2 diabetes mellituspathogenesisprotein metabolismcytokinesinsulin resistanceNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 4, Pp 49-51 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN RU |
| topic |
type 2 diabetes mellitus pathogenesis protein metabolism cytokines insulin resistance Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
type 2 diabetes mellitus pathogenesis protein metabolism cytokines insulin resistance Nutritional diseases. Deficiency diseases RC620-627 Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev Novel approach to pathophysiology of type 2 diabetes mellitus |
| description |
In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance during the absorption period. We also discuss the effects on energy homeostasis exercised by cytokines via mTOR pathway (the key factor of insulin signalling) considering the phenomenon of insulin resistance. |
| format |
article |
| author |
Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev |
| author_facet |
Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev |
| author_sort |
Emil' Kopeevich Mukhamedzhanov |
| title |
Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_short |
Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_full |
Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_fullStr |
Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_full_unstemmed |
Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_sort |
novel approach to pathophysiology of type 2 diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2013 |
| url |
https://doaj.org/article/c27ad7942a704513b503d3618588a6ae |
| work_keys_str_mv |
AT emilkopeevichmukhamedzhanov novelapproachtopathophysiologyoftype2diabetesmellitus AT olegviktorovichesyrev novelapproachtopathophysiologyoftype2diabetesmellitus |
| _version_ |
1718429611486871552 |