Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cells and that AURKA inhibition sensitizes these cell...

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Main Authors:	Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, Changjie Wu, Lakhansing Pardeshi, Changxiang Shi, Pui Kei Mou, Yifan Liu, Kaeling Tan, Joong Sup Shim
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c
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spelling	oai:doaj.org-article:c27f425a63c3424e81e7e45850e9e42c2021-12-02T18:09:04ZSynthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics10.1038/s41467-020-18872-02041-1723https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18872-0https://doaj.org/toc/2041-1723Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cells and that AURKA inhibition sensitizes these cells to mitotic cell death.Junfang LyuEun Ju YangBaoyuan ZhangChangjie WuLakhansing PardeshiChangxiang ShiPui Kei MouYifan LiuKaeling TanJoong Sup ShimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junfang Lyu Eun Ju Yang Baoyuan Zhang Changjie Wu Lakhansing Pardeshi Changxiang Shi Pui Kei Mou Yifan Liu Kaeling Tan Joong Sup Shim Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
description	Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cells and that AURKA inhibition sensitizes these cells to mitotic cell death.
format	article
author	Junfang Lyu Eun Ju Yang Baoyuan Zhang Changjie Wu Lakhansing Pardeshi Changxiang Shi Pui Kei Mou Yifan Liu Kaeling Tan Joong Sup Shim
author_facet	Junfang Lyu Eun Ju Yang Baoyuan Zhang Changjie Wu Lakhansing Pardeshi Changxiang Shi Pui Kei Mou Yifan Liu Kaeling Tan Joong Sup Shim
author_sort	Junfang Lyu
title	Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
title_short	Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
title_full	Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
title_fullStr	Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
title_full_unstemmed	Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics
title_sort	synthetic lethality of rb1 and aurora a is driven by stathmin-mediated disruption of microtubule dynamics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c
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Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

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