Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cells and that AURKA inhibition sensitizes these cell...

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Autores principales: Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, Changjie Wu, Lakhansing Pardeshi, Changxiang Shi, Pui Kei Mou, Yifan Liu, Kaeling Tan, Joong Sup Shim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c
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