Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation

Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.

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Autores principales:	Karen Brami-Cherrier, Robert G. Lewis, Marlene Cervantes, Yu Liu, Paola Tognini, Pierre Baldi, Paolo Sassone-Corsi, Emiliana Borrelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c282946d5e1a46288300a2c2c50d829c
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spelling	oai:doaj.org-article:c282946d5e1a46288300a2c2c50d829c2021-12-02T19:12:26ZCocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation10.1038/s41467-020-18200-62041-1723https://doaj.org/article/c282946d5e1a46288300a2c2c50d829c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18200-6https://doaj.org/toc/2041-1723Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.Karen Brami-CherrierRobert G. LewisMarlene CervantesYu LiuPaola TogniniPierre BaldiPaolo Sassone-CorsiEmiliana BorrelliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen Brami-Cherrier Robert G. Lewis Marlene Cervantes Yu Liu Paola Tognini Pierre Baldi Paolo Sassone-Corsi Emiliana Borrelli Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
description	Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.
format	article
author	Karen Brami-Cherrier Robert G. Lewis Marlene Cervantes Yu Liu Paola Tognini Pierre Baldi Paolo Sassone-Corsi Emiliana Borrelli
author_facet	Karen Brami-Cherrier Robert G. Lewis Marlene Cervantes Yu Liu Paola Tognini Pierre Baldi Paolo Sassone-Corsi Emiliana Borrelli
author_sort	Karen Brami-Cherrier
title	Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
title_short	Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
title_full	Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
title_fullStr	Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
title_full_unstemmed	Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
title_sort	cocaine-mediated circadian reprogramming in the striatum through dopamine d2r and pparγ activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c282946d5e1a46288300a2c2c50d829c
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Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation

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